Gröschel Moritz, Götze Romy, Müller Susanne, Ernst Arne, Basta Dietmar
Department of Otolaryngology, Unfallkrankenhaus Berlin, Charité Medical School, Berlin, Germany.
Neuroscience Research Center (NWFZ), Charité Medical School, Berlin, Germany.
PLoS One. 2016 Apr 14;11(4):e0153386. doi: 10.1371/journal.pone.0153386. eCollection 2016.
This study investigated the effect of systemic salicylate on central auditory and non-auditory structures in mice. Since cochlear hair cells are known to be one major target of salicylate, cochlear effects were reduced by using kanamycin to remove or impair hair cells. Neuronal brain activity was measured using the non-invasive manganese-enhanced magnetic resonance imaging technique. For all brain structures investigated, calcium-related neuronal activity was increased following systemic application of a sodium salicylate solution: probably due to neuronal hyperactivity. In addition, it was shown that the central effect of salicylate was not limited to the auditory system. A general alteration of calcium-related activity was indicated by an increase in manganese accumulation in the preoptic area of the anterior hypothalamus, as well as in the amygdala. The present data suggest that salicylate-induced activity changes in the auditory system differ from those shown in studies of noise trauma. Since salicylate action is reversible, central pharmacological effects of salicylate compared to those of (permanent) noise-induced hearing impairment and tinnitus might induce different pathophysiologies. These should therefore, be treated as different causes with the same symptoms.
本研究调查了全身应用水杨酸盐对小鼠中枢听觉及非听觉结构的影响。由于已知耳蜗毛细胞是水杨酸盐的一个主要靶点，因此通过使用卡那霉素去除或损伤毛细胞来减轻耳蜗效应。使用非侵入性锰增强磁共振成像技术测量神经元脑活动。对于所研究的所有脑结构，全身应用水杨酸钠溶液后，与钙相关的神经元活动增加：这可能是由于神经元活动亢进所致。此外，研究表明水杨酸盐的中枢效应并不局限于听觉系统。下丘脑前部视前区以及杏仁核中锰积累的增加表明与钙相关的活动发生了普遍改变。目前的数据表明，水杨酸盐在听觉系统中引起的活动变化与噪声创伤研究中显示的不同。由于水杨酸盐的作用是可逆的，与（永久性）噪声性听力损失和耳鸣相比，水杨酸盐的中枢药理作用可能会引发不同的病理生理学。因此，这些应被视为具有相同症状的不同病因。
