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瑞士急性ST段抬高型心肌梗死急诊患者的血运重建治疗:2010 - 2011年瑞士全国性横断面研究结果

Revascularization Treatment of Emergency Patients with Acute ST-Segment Elevation Myocardial Infarction in Switzerland: Results from a Nationwide, Cross-Sectional Study in Switzerland for 2010-2011.

作者信息

Berlin Claudia, Jüni Peter, Endrich Olga, Zwahlen Marcel

机构信息

Institute of Social and Preventive Medicine (ISPM), University of Bern, Bern, Switzerland.

Applied Health Research Centre (AHRC), Li Ka Shing Knowledge Institute of St. Michael's Hospital, and Department of Medicine, University of Toronto, Toronto, Canada.

出版信息

PLoS One. 2016 Apr 14;11(4):e0153326. doi: 10.1371/journal.pone.0153326. eCollection 2016.

Abstract

BACKGROUND

Cardiovascular diseases are the leading cause of death worldwide and in Switzerland. When applied, treatment guidelines for patients with acute ST-segment elevation myocardial infarction (STEMI) improve the clinical outcome and should eliminate treatment differences by sex and age for patients whose clinical situations are identical. In Switzerland, the rate at which STEMI patients receive revascularization may vary by patient and hospital characteristics.

AIMS

To examine all hospitalizations in Switzerland from 2010-2011 to determine if patient or hospital characteristics affected the rate of revascularization (receiving either a percutaneous coronary intervention or a coronary artery bypass grafting) in acute STEMI patients.

DATA AND METHODS

We used national data sets on hospital stays, and on hospital infrastructure and operating characteristics, for the years 2010 and 2011, to identify all emergency patients admitted with the main diagnosis of acute STEMI. We then calculated the proportion of patients who were treated with revascularization. We used multivariable multilevel Poisson regression to determine if receipt of revascularization varied by patient and hospital characteristics.

RESULTS

Of the 9,696 cases we identified, 71.6% received revascularization. Patients were less likely to receive revascularization if they were female, and 80 years or older. In the multivariable multilevel Poisson regression analysis, there was a trend for small-volume hospitals performing fewer revascularizations but this was not statistically significant while being female (Relative Proportion = 0.91, 95% CI: 0.86 to 0.97) and being older than 80 years was still associated with less frequent revascularization.

CONCLUSION

Female and older patients were less likely to receive revascularization. Further research needs to clarify whether this reflects differential application of treatment guidelines or limitations in this kind of routine data.

摘要

背景

心血管疾病是全球及瑞士的主要死因。急性ST段抬高型心肌梗死(STEMI)患者应用治疗指南可改善临床结局,且对于临床情况相同的患者,应消除性别和年龄造成的治疗差异。在瑞士,STEMI患者接受血运重建的比例可能因患者和医院特征而异。

目的

研究2010 - 2011年瑞士所有住院病例,以确定患者或医院特征是否影响急性STEMI患者的血运重建率(接受经皮冠状动脉介入治疗或冠状动脉旁路移植术)。

数据与方法

我们使用了2010年和2011年全国住院患者数据集以及医院基础设施和运营特征数据集,以确定所有主要诊断为急性STEMI的急诊患者。然后计算接受血运重建治疗的患者比例。我们使用多变量多水平泊松回归来确定血运重建的接受情况是否因患者和医院特征而异。

结果

在我们确定的9696例病例中,71.6%接受了血运重建。女性患者以及80岁及以上患者接受血运重建的可能性较小。在多变量多水平泊松回归分析中,规模较小的医院进行血运重建的例数有减少趋势,但无统计学意义,而女性(相对比例 = 0.91,95%可信区间:0.86至0.97)和80岁以上患者接受血运重建的频率仍然较低。

结论

女性和老年患者接受血运重建的可能性较小。需要进一步研究来阐明这是否反映了治疗指南的不同应用或这类常规数据的局限性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e6e5/4831744/13ffee3b9006/pone.0153326.g001.jpg

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