González Gili Lucas O, Buffone Ignacio R, Carrara Laura E, Coto María B, Fortunatti Eliana A, Dejtera Mabel, García Elliot María F, Giacone Alejandra, Luncio Anabella C, Masnicoff Sebastián D, Oviedo Crosta María B, Parroua Marianela, Romano Mariana
Hospital Municipal de Agudos "Dr. Leónidas Lucero", Bahía Blanca, Buenos Aires, 8000, Argentina.
Arch Argent Pediatr. 2016 Apr;114(2):e78-83. doi: 10.5546/aap.2016.e78. Epub 2016 Apr 1.
Pseudotumor cerebri is a syndrome characterized by an elevated intracranial pressure greater than 20 cmH2O with ventricles and cerebrospinal fluid of normal characteristics. Consumption of minocycline have been described among the causes associated with this syndrome. We present a 13-year old female patient with a history of acne treated with minocycline who began with severe headache, diplopia and blurred vision. The diagnosis of pseudotumor cerebri was made, indicating the immediate antibiotic suspension and the beginning of the treatment with acetazolamide. Although the pathogenesis of pseudotumor cerebri is not fully known, an association with minocycline has been observed. This antibiotic is often used by health professionals for the management of acne, so it is important to consider its complications before being prescribed.
假性脑瘤是一种综合征，其特征为颅内压升高超过20 cmH₂O，而脑室和脑脊液特征正常。米诺环素的使用已被列为与该综合征相关的病因之一。我们报告一名13岁女性患者，有痤疮病史，曾用米诺环素治疗，现出现严重头痛、复视和视力模糊。诊断为假性脑瘤，遂立即停用抗生素，并开始使用乙酰唑胺治疗。尽管假性脑瘤的发病机制尚不完全清楚，但已观察到与米诺环素有关联。这种抗生素常用于医疗专业人员治疗痤疮，因此在开处方前考虑其并发症很重要。
