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N-Methyl-D-Aspartate Receptors, Ketamine, and Rett Syndrome: Something Special on the Road to Treatments?

作者信息

Katz David M, Menniti Frank S, Mather Robert J

机构信息

Departments of Neurosciences and Psychiatry, Case Western Reserve University School of Medicine, Cleveland, Ohio.

MindImmune Therapeutics (FSM), Kingston, Rhode Island.

出版信息

Biol Psychiatry. 2016 May 1;79(9):710-2. doi: 10.1016/j.biopsych.2016.03.1045.

DOI:10.1016/j.biopsych.2016.03.1045
PMID:27079494
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4924879/
Abstract
摘要

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本文引用的文献

1
Rett Syndrome: Crossing the Threshold to Clinical Translation.雷特综合征：迈向临床转化的关键一步。
Trends Neurosci. 2016 Feb;39(2):100-113. doi: 10.1016/j.tins.2015.12.008.
2
Chronic Administration of the N-Methyl-D-Aspartate Receptor Antagonist Ketamine Improves Rett Syndrome Phenotype.长期给予 N-甲基-D-天冬氨酸受体拮抗剂氯胺酮可改善雷特综合征表型。
Biol Psychiatry. 2016 May 1;79(9):755-764. doi: 10.1016/j.biopsych.2015.08.018. Epub 2015 Aug 24.
3
Cell-Specific Regulation of N-Methyl-D-Aspartate Receptor Maturation by Mecp2 in Cortical Circuits.Mecp2在皮质回路中对N-甲基-D-天冬氨酸受体成熟的细胞特异性调控
Biol Psychiatry. 2016 May 1;79(9):746-754. doi: 10.1016/j.biopsych.2015.05.018. Epub 2015 Jun 5.
4
NMDA receptors subserve persistent neuronal firing during working memory in dorsolateral prefrontal cortex.NMDA 受体在后外侧前额叶皮层的工作记忆中持续激发神经元放电。
Neuron. 2013 Feb 20;77(4):736-49. doi: 10.1016/j.neuron.2012.12.032.
5
NMDA receptor regulation prevents regression of visual cortical function in the absence of Mecp2.NMDA 受体调节可防止 Mecp2 缺失时视觉皮层功能的退化。
Neuron. 2012 Dec 20;76(6):1078-90. doi: 10.1016/j.neuron.2012.12.004.
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Use of ketamine during procedural sedation: indications, controversies, and side effects.程序性镇静期间氯胺酮的使用：适应证、争议及副作用。
J Infus Nurs. 2012 Nov-Dec;35(6):377-82. doi: 10.1097/NAN.0b013e31827068c1.
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Brain activity mapping in Mecp2 mutant mice reveals functional deficits in forebrain circuits, including key nodes in the default mode network, that are reversed with ketamine treatment.在 Mecp2 突变小鼠中进行脑活动图谱绘制揭示了前脑回路的功能缺陷，包括默认模式网络中的关键节点，这些缺陷可以通过氯胺酮治疗得到逆转。
J Neurosci. 2012 Oct 3;32(40):13860-72. doi: 10.1523/JNEUROSCI.2159-12.2012.
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Reversal of neurological defects in a mouse model of Rett syndrome.雷特综合征小鼠模型中神经缺陷的逆转
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Changing subunit composition of heteromeric NMDA receptors during development of rat cortex.大鼠皮质发育过程中异聚体N-甲基-D-天冬氨酸受体亚基组成的变化
Nature. 1994 Mar 10;368(6467):144-7. doi: 10.1038/368144a0.