Song Sarah, Fonarow Gregg C, Olson DaiWai M, Liang Li, Schulte Phillip J, Hernandez Adrian F, Peterson Eric D, Reeves Mathew J, Smith Eric E, Schwamm Lee H, Saver Jeffrey L
From the Department of Neurology, Rush University Medical Center, Chicago, IL (S.S.); Departments of Cardiology (G.C.F.) and Neurology (J.L.S.), University of California, Los Angeles; Department of Neurology, University of Texas-Southwestern, Dallas (D.M.O.); Departments of Biostatistics and Bioinformatics (L.L., P.J.S.) and Cardiology (A.F.H., E.D.P.), Duke University, Durham, NC; Department of Epidemiology and Biostatistics, Michigan State University, East Lansing (M.J.R.); Department of Clinical Neurosciences, Hotchkiss Brain Institute, University of Calgary, Calgary, Alberta, Canada (E.E.S.); and Department of Neurology, Massachusetts General Hospital, Boston (L.H.S.).
Stroke. 2016 May;47(5):1294-302. doi: 10.1161/STROKEAHA.115.011874. Epub 2016 Apr 14.
Get With The Guidelines (GWTG)-Stroke is a national, hospital-based quality improvement program developed by the American Heart Association. Although studies have suggested improved processes of care in GWTG-Stroke-participating hospitals, it is not known whether this improved care translates into improved clinical outcomes compared with nonparticipating hospitals.
From all acute care US hospitals caring for Medicare beneficiaries with acute stroke between April 2003 and December 2008, we matched hospitals that joined the GWTG-Stroke program with similar hospitals that did not. Using a difference-in-differences design, we analyzed whether hospital participation in GWTG-Stroke was associated with a greater improvement in clinical outcomes compared with the underlying secular change.
The matching algorithm identified 366 GWTG-Stroke-adopting hospitals that cared for 88 584 acute ischemic stroke admissions and 366 non-GWTG-Stroke hospitals that cared for 85 401 acute ischemic stroke admissions. Compared with the Pre period (18-6 months before program implementation), in the Early period (0-6 months after program implementation), GWTG-Stroke hospitals had accelerated increases in discharge to home and reduced mortality at 30 days and 1 year. In the Sustained period (6-18 months after program implementation), the accelerated reduction in mortality at 1 year was sustained, with a trend toward sustained accelerated increase in discharge home.
Hospital adoption of the GWTG-Stroke program was associated with improved functional outcomes at discharge and reduced postdischarge mortality.
“遵循指南-卒中”(GWTG-卒中)是美国心脏协会开展的一项全国性、以医院为基础的质量改进项目。尽管研究表明参与GWTG-卒中项目的医院护理流程有所改善,但与未参与的医院相比,这种改善的护理是否能转化为更好的临床结局尚不清楚。
从2003年4月至2008年12月期间为患有急性卒中的医疗保险受益人提供护理的所有美国急性护理医院中,我们将加入GWTG-卒中项目的医院与未加入的类似医院进行匹配。采用差异中的差异设计,我们分析了与潜在的长期变化相比,医院参与GWTG-卒中项目是否与临床结局的更大改善相关。
匹配算法确定了366家采用GWTG-卒中项目的医院,这些医院护理了88584例急性缺血性卒中入院患者,以及366家未采用GWTG-卒中项目的医院,这些医院护理了85401例急性缺血性卒中入院患者。与项目实施前时期(项目实施前18至6个月)相比,在早期(项目实施后0至6个月),GWTG-卒中项目医院回家出院的加速增加,30天和1年时死亡率降低。在持续期(项目实施后6至18个月),1年时死亡率的加速降低得以持续,回家出院持续加速增加的趋势也存在。
医院采用GWTG-卒中项目与出院时功能结局改善和出院后死亡率降低相关。