Polymeric networks for controlled release of drugs: a patent review.

INTRODUCTION

Polymeric networks for controlled drug delivery possess wide pharmaceutical and biomedical applications.

AREAS COVERED

In this review, we explore the diversity of polymeric networks that exist, from simple to highly complex and 'smart' embodiments. The patented delivery systems reviewed reflect this, based on both conventional polymeric networks and stimulus-responsive networks where engineering of a controlled molecular architecture of polymeric networks enables a defined response to external or internal stimuli. Future trends in terms of nano-sized polymeric network patents are also highlighted.

EXPERT OPINION

A critical analysis of challenges potentially facing extended propulsion of the research and development of polymeric networks is provided. The significant therapeutic potential of polymer networks for controlled drug delivery is highlighted in the patented drug delivery systems examined; however, there needs to be enhanced representation of such systems in the market and thus available to patients. Concerted efforts are therefore necessary to propel these systems from the experimental setting to pilot scale production, and preclinical and clinical testing, for extension of their practicality.