du Toit Lisa C, Choonara Yahya E, Kumar Pradeep, Pillay Viness
a Wits Advanced Drug Delivery Platform Research Unit, Department of Pharmacy and Pharmacology, School of Therapeutic Sciences, Faculty of Health Sciences , University of the Witwatersrand , Johannesburg , South Africa.
Expert Opin Ther Pat. 2016 Jun;26(6):703-17. doi: 10.1080/13543776.2016.1178720. Epub 2016 Apr 27.
Polymeric networks for controlled drug delivery possess wide pharmaceutical and biomedical applications.
In this review, we explore the diversity of polymeric networks that exist, from simple to highly complex and 'smart' embodiments. The patented delivery systems reviewed reflect this, based on both conventional polymeric networks and stimulus-responsive networks where engineering of a controlled molecular architecture of polymeric networks enables a defined response to external or internal stimuli. Future trends in terms of nano-sized polymeric network patents are also highlighted.
A critical analysis of challenges potentially facing extended propulsion of the research and development of polymeric networks is provided. The significant therapeutic potential of polymer networks for controlled drug delivery is highlighted in the patented drug delivery systems examined; however, there needs to be enhanced representation of such systems in the market and thus available to patients. Concerted efforts are therefore necessary to propel these systems from the experimental setting to pilot scale production, and preclinical and clinical testing, for extension of their practicality.
用于控释药物的聚合物网络具有广泛的制药和生物医学应用。
在本综述中，我们探讨了现有的聚合物网络的多样性，从简单到高度复杂以及“智能”的形式。所综述的专利递送系统反映了这一点，其基于传统聚合物网络和刺激响应网络，其中聚合物网络的可控分子结构工程能够对外部或内部刺激产生明确的响应。还强调了纳米级聚合物网络专利方面的未来趋势。
对聚合物网络研发进一步推进可能面临的挑战进行了批判性分析。在所研究的专利药物递送系统中突出了聚合物网络用于控释药物的巨大治疗潜力；然而，此类系统在市场上的代表性需要提高，从而可供患者使用。因此，需要共同努力将这些系统从实验阶段推进到中试规模生产以及临床前和临床试验，以扩大其实用性。
