Nava-Arzaluz María G, Piñón-Segundo Elizabeth, Ganem-Rondero Adriana, Lechuga-Ballesteros David
Laboratorio de Investigacion y Posgrado en Tecnologia Farmaceutica, Facultad de Estudios Superiores Cuautitlan, Universidad Nacional Autonoma de Mexico. Av 1 de Mayo s/n, Col. Santa Maria las Torres, Cuautitlan Izcalli, Estado de Mexico, 54740, Mexico.
Recent Pat Drug Deliv Formul. 2012 Dec;6(3):209-23. doi: 10.2174/187221112802652633.
In recent years, there has been an increased interest in using nanoparticles for drug delivery and pharmaceutical development. Nanoparticles can offer significant advantages over the conventional drug delivery systems in terms of high drug loading, stability and specificity, controlled release capability, and the ability to deliver both hydrophilic and hydrophobic drug molecules through various routes of administration. This review article focuses on the use of the single emulsion solvent evaporation method, the first method proposed for the preparation of polymeric nanoparticles, and modifications that have been developed over the years to improve the results obtained with this technique.
近年来，人们对使用纳米颗粒进行药物递送和药物研发的兴趣日益增加。与传统药物递送系统相比，纳米颗粒在高药物负载量、稳定性和特异性、控释能力以及通过各种给药途径递送亲水性和疏水性药物分子的能力方面具有显著优势。这篇综述文章重点介绍了单乳液溶剂蒸发法的应用，该方法是最早提出的用于制备聚合物纳米颗粒的方法，以及多年来为改进该技术所取得的成果而开发的改进方法。
