Behler Oliver, Uppenkamp Stefan
Medizinische Physik, Carl von Ossietzky Universität Oldenburg, 26111, Oldenburg, Germany.
Medizinische Physik and Cluster of Excellence Hearing4All, Carl von Ossietzky Universität Oldenburg, 26111, Oldenburg, Germany.
Adv Exp Med Biol. 2016;894:165-174. doi: 10.1007/978-3-319-25474-6_18.
We report a systematic exploration of the interrelation of sound intensity, ear of entry, individual loudness judgments, and brain activity across hemispheres, using auditory functional magnetic resonance imaging (fMRI). The stimuli employed were 4 kHz-bandpass filtered noise stimuli, presented monaurally to each ear at levels from 37 to 97 dB SPL. One diotic condition and a silence condition were included as control conditions. Normal hearing listeners completed a categorical loudness scaling procedure with similar stimuli before auditory fMRI was performed. The relationship between brain activity, as inferred from blood oxygenation level dependent (BOLD) contrasts, and both sound intensity and loudness estimates were analyzed by means of linear mixed effects models for various anatomically defined regions of interest in the ascending auditory pathway and in the cortex. The results indicate distinct functional differences between midbrain and cortical areas as well as between specific regions within auditory cortex, suggesting a systematic hierarchy in terms of lateralization and the representation of sensory stimulation and perception.
我们报告了一项系统性研究，利用听觉功能磁共振成像（fMRI）探索声音强度、声音传入耳朵的位置、个体响度判断以及大脑半球间活动的相互关系。所使用的刺激是4kHz带通滤波噪声刺激，以37至97dB SPL的水平单耳呈现给每只耳朵。一个双耳条件和一个安静条件作为对照条件。听力正常的受试者在进行听觉fMRI之前，用类似的刺激完成了一个分类响度标度程序。通过线性混合效应模型，对听觉上行通路和皮层中各种解剖学定义的感兴趣区域，分析了从血氧水平依赖（BOLD）对比推断出的大脑活动与声音强度和响度估计之间的关系。结果表明中脑和皮层区域之间以及听觉皮层内特定区域之间存在明显的功能差异，这表明在侧化以及感觉刺激和感知的表征方面存在系统层次结构。
