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Successful Pain Management with Epidural Oxytocin.

作者信息

Condés-Lara Miguel, Zayas-González Héctor, Manzano-García Alfredo, Córdova-Quiroz Estefanía, Granados-Mortera Juan, García-Cuevas Marco, Morales-Gómez Julio, González-Hernández Abimael

机构信息

Departamento de Neurobiología del Desarrollo y Neurofisiología, Instituto de Neurobiología, Universidad Nacional Autónoma de México, Querétaro, México.

Hospital Regional de Petróleos Mexicanos, Salamanca, Guanajuato, México.

出版信息

CNS Neurosci Ther. 2016 Jun;22(6):532-4. doi: 10.1111/cns.12551. Epub 2016 Apr 15.

DOI:10.1111/cns.12551
PMID:27080720
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6492780/
Abstract
摘要

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Successful Pain Management with Epidural Oxytocin.硬膜外注射催产素成功进行疼痛管理。
CNS Neurosci Ther. 2016 Jun;22(6):532-4. doi: 10.1111/cns.12551. Epub 2016 Apr 15.
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Epidural narcotic use for outpatient pain treatment.门诊疼痛治疗中硬膜外使用麻醉剂。
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Intrathecal injections of non-peptide oxytocin receptor agonists, WAY 267,464 and TC OT 39, induce significant anti-hyperalgesia in both male and female rats with inflammatory pain.鞘内注射非肽类催产素受体激动剂WAY 267,464和TC OT 39，可在患有炎性疼痛的雄性和雌性大鼠中诱导出显著的抗痛觉过敏作用。
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Evaluating the efficacy of oxytocin for pain management: An updated systematic review and meta-analysis of randomized clinical trials and observational studies.评估催产素用于疼痛管理的疗效：对随机临床试验和观察性研究的最新系统评价与荟萃分析。
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Ethical Concerns Regarding Human Study.关于人体研究的伦理问题。
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Response to Letter to the Editor by Eisenach and Yaksh on "Successful Pain Management with Epidural Oxytocin".对艾森纳克和亚克什就《硬膜外注射催产素成功进行疼痛管理》致编辑信的回复。
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本文引用的文献

1
Phase 1 safety assessment of intrathecal oxytocin.鞘内给予催产素的 1 期安全性评估。
Anesthesiology. 2015 Feb;122(2):407-13. doi: 10.1097/ALN.0000000000000539.
2
Intranasal Oxytocin Administration is Associated With Enhanced Endogenous Pain Inhibition and Reduced Negative Mood States.经鼻给予催产素与内源性疼痛抑制增强及负面情绪状态减轻有关。
Clin J Pain. 2015 Sep;31(9):757-767. doi: 10.1097/AJP.0000000000000166.
3
Oxytocin and analgesia: future trends.催产素与镇痛：未来趋势
Trends Pharmacol Sci. 2014 Nov;35(11):549-51. doi: 10.1016/j.tips.2014.09.004. Epub 2014 Sep 27.
4
Preclinical toxicity screening of intrathecal oxytocin in rats and dogs.鞘内给予催产素在大鼠和犬的临床前毒性筛选。
Anesthesiology. 2014 Apr;120(4):951-61. doi: 10.1097/ALN.0000000000000148.
5
Oxytocin and pain: a systematic review and synthesis of findings.催产素与疼痛：研究结果的系统评价与综合分析
Clin J Pain. 2014 May;30(5):453-62. doi: 10.1097/AJP.0b013e31829f57df.
6
Distribution and identity of neurons expressing the oxytocin receptor in the mouse spinal cord.在小鼠脊髓中表达催产素受体的神经元的分布和特性。
Neurosci Lett. 2011 May 9;495(1):49-54. doi: 10.1016/j.neulet.2011.03.033. Epub 2011 Mar 23.
7
Distribution of vasopressin and oxytocin binding sites in the brain and upper spinal cord of the common marmoset.普通狨猴大脑和上脊髓中血管加压素和催产素结合位点的分布。
Neurosci Lett. 2009 Sep 25;461(3):217-22. doi: 10.1016/j.neulet.2009.06.016. Epub 2009 Jun 17.
8
PVN electrical stimulation prolongs withdrawal latencies and releases oxytocin in cerebrospinal fluid, plasma, and spinal cord tissue in intact and neuropathic rats.在完整和神经性大鼠中，室旁核电刺激可延长撤药潜伏期，并使脑脊液、血浆和脊髓组织中的催产素释放。
Pain. 2008 Nov 30;140(2):265-273. doi: 10.1016/j.pain.2008.08.015. Epub 2008 Sep 26.
9
Oxytocin and electrical stimulation of the paraventricular hypothalamic nucleus produce antinociceptive effects that are reversed by an oxytocin antagonist.催产素和下丘脑室旁核的电刺激产生的镇痛作用可被一种催产素拮抗剂逆转。
Pain. 2006 May;122(1-2):182-9. doi: 10.1016/j.pain.2006.01.029. Epub 2006 Mar 9.
10
Intraventricular somatostatin-14, arginine vasopressin, and oxytocin: analgesic effect in a patient with intractable cancer pain.脑室内生长抑素-14、精氨酸加压素和催产素：对一名顽固性癌痛患者的镇痛作用
Appl Neurophysiol. 1987;50(1-6):427-31. doi: 10.1159/000100753.