Laurell G, Engström B
Institute of Physiology II, Karolinska Institute, Stockholm, Sweden.
Hear Res. 1989 Mar;38(1-2):27-33. doi: 10.1016/0378-5955(89)90125-1.
The effect on the electrophysiological hearing thresholds and the endocochlear DC potential (EP) was studied in four groups of guinea pigs receiving different doses of cisplatin. By multiple low-dose intraperitoneal injections a permanent hearing loss was produced without a permanent decrease of the EP. On the other hand, when cisplatin was given as a single high-dose intravenous injection, there was an impairment of the electrophysiological hearing thresholds and EP, depending upon the level of cisplatin dose. It is concluded that cisplatin-induced hearing loss is not necessarily a sequela to a loss of EP.
研究了四组接受不同剂量顺铂的豚鼠的电生理听力阈值和内淋巴直流电位（EP）的影响。通过多次低剂量腹腔注射产生了永久性听力损失，但EP没有永久性下降。另一方面，当以单次高剂量静脉注射给予顺铂时，电生理听力阈值和EP会受到损害，这取决于顺铂剂量水平。得出的结论是，顺铂诱导的听力损失不一定是EP丧失的后遗症。
