García Sáez Ana J, Villunger Andreas
Interfaculty Institute of Biochemistry (IFIB), University of Tübingen 72076, Tübingen, Germany;
Division of Developmental Immunology, Biocenter, Medical University Innsbruck, A-6020 Innsbruck, Austria; Tyrolean Cancer Research Institute, A-6020 Innsbruck, Austria.
Genes Dev. 2016 Apr 15;30(8):878-80. doi: 10.1101/gad.281519.116.
The minimum requirement for mitochondrial apoptosis has been controversial ever since the discovery of BCL-2 as a cell death regulator. In this issue ofGenes&Development, O'Neill and colleagues (pp. 973-988) end a long-standing debate by creating a cellular system free of BCL-2 family proteins, thereby identifying the outer mitochondrial membrane rather than BH3-only proteins as the only requirement for BAX/BAK activation and mitochondrial outer membrane permeabilization (MOMP).
自BCL-2作为细胞死亡调节因子被发现以来，线粒体凋亡的最低要求一直存在争议。在本期《基因与发育》杂志中，奥尼尔及其同事（第973 - 988页）通过构建一个不含BCL-2家族蛋白的细胞系统，结束了一场长期的争论，从而确定线粒体外膜而非仅含BH3结构域的蛋白是BAX/BAK激活和线粒体膜通透性转换（MOMP）的唯一必要条件。
Zotero 插件