Saeed Hamid, Ahsan Muhammad, Saleem Zikria, Iqtedar Mehwish, Islam Muhammad, Danish Zeeshan, Khan Asif Manzoor
Section of Clinical Pharmacy, University College of Pharmacy, University of the Punjab, Allama Iqbal Campus, 54000, Lahore, Pakistan.
Department of Bio-technology, Lahore College for Women University, Lahore, Pakistan.
J Biomed Sci. 2016 Apr 16;23:41. doi: 10.1186/s12929-016-0254-3.
Mesenchymal stem cells hold the promise to treat not only several congenital and acquired bone degenerative diseases but also to repair and regenerate morbid bone tissues. Utilizing MSCs, several lines of evidences advocate promising clinical outcomes in skeletal diseases and skeletal tissue repair/regeneration. In this context, both, autologous and allogeneic cell transfer options have been utilized. Studies suggest that MSCs are transplanted either alone by mixing with autogenous plasma/serum or by loading onto repair/induction supportive resorb-able scaffolds. Thus, this review is aimed at highlighting a wide range of pertinent clinical therapeutic options of MSCs in the treatment of skeletal diseases and skeletal tissue regeneration. Additionally, in skeletal disease and regenerative sections, only the early and more recent preclinical evidences are discussed followed by all the pertinent clinical studies. Moreover, germane post transplant therapeutic mechanisms afforded by MSCs have also been conversed. Nonetheless, assertive use of MSCs in the clinic for skeletal disorders and repair is far from a mature therapeutic option, therefore, posed challenges and future directions are also discussed. Importantly, for uniformity at all instances, term MSCs is used throughout the review.
间充质干细胞不仅有望治疗多种先天性和后天性骨退行性疾病，还能修复和再生病态骨组织。利用间充质干细胞，多项证据表明在骨骼疾病和骨骼组织修复/再生方面有良好的临床效果。在此背景下，自体和异体细胞移植方法均已被采用。研究表明，间充质干细胞要么与自体血浆/血清混合单独移植，要么负载于修复/诱导支持性可吸收支架上进行移植。因此，本综述旨在突出间充质干细胞在治疗骨骼疾病和骨骼组织再生方面的一系列相关临床治疗选择。此外，在骨骼疾病和再生部分，仅讨论早期和最新的临床前证据，随后是所有相关临床研究。而且，还讨论了间充质干细胞提供的相关移植后治疗机制。尽管如此，在临床上果断使用间充质干细胞治疗骨骼疾病和进行修复远非成熟的治疗选择，因此，也讨论了所面临的挑战和未来方向。重要的是，为保持始终一致，本综述通篇使用“间充质干细胞”这一术语。
