Department of Epidemiology and Preventive Medicine, School of Public Health and Preventive Medicine, Monash University, Alfred Hospital, Melbourne, VIC 3004, Australia.
Department of Epidemiology and Preventive Medicine, School of Public Health and Preventive Medicine, Monash University, Alfred Hospital, Melbourne, VIC 3004, Australia; Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Carlton, VIC 3053, Australia; Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, VIC 3004, Australia.
Osteoarthritis Cartilage. 2016 Aug;24(8):1408-12. doi: 10.1016/j.joca.2016.04.008. Epub 2016 Apr 12.
Few studies have examined the association between circulating sex steroid concentrations and risk of osteoarthritis (OA) in men with inconsistent results. Our aim was to examine whether concentrations of circulating sex steroid hormones were associated with the incidence of primary knee and hip arthroplasty for OA in a prospective cohort study.
Two thousand four hundred and ninety four men from the Melbourne Collaborative Cohort Study (MCCS) had circulating sex steroid concentrations measured in blood samples drawn at recruitment (1990-1994) and stored in liquid nitrogen. The plasma concentrations of sex hormones, including dehydroepiandrosterone sulphate, androstenedione, testosterone, estradiol, androstanediol glucuronide, and sex hormone binding globulin, were measured. The incidence of total knee and hip arthroplasty for OA during 2001-2013 was determined by linking MCCS records to the Australian Orthopaedic Association National Joint Replacement Registry.
One hundred and four men had knee and 80 had hip arthroplasty for OA over 10.7 (SD 3.8) years. Higher concentrations of androstenedione were associated with a decreased risk of total knee (hazard ratio (HR) 0.87, 95% confidence interval (CI) 0.77-0.98) and hip (HR 0.84 95% CI 0.71-1.00) arthroplasty for OA in overweight and obese men. No significant association was observed for the other measured hormones.
Low plasma androstenedione concentration is associated with an increased risk of both knee and hip arthroplasty for OA for overweight and obese men. While the findings need to be confirmed in other cohort studies, they suggest that circulating sex steroids may play a role in the pathogenesis of OA in men.
很少有研究检查循环性激素浓度与男性骨关节炎（OA）风险之间的关系，结果不一致。我们的目的是在一项前瞻性队列研究中检查循环性激素浓度是否与原发性膝关节和髋关节 OA 关节置换的发生率有关。
2494 名来自墨尔本合作队列研究（MCCS）的男性在招募时（1990-1994 年）采集血液样本，并储存在液氮中，以测量循环性激素浓度，包括硫酸脱氢表雄酮、雄烯二酮、睾酮、雌二醇、雄烷二醇葡萄糖醛酸和性激素结合球蛋白。通过将 MCCS 记录与澳大利亚矫形协会全国关节置换登记处联系起来，确定 2001-2013 年期间膝关节和髋关节 OA 的总关节置换发生率。
104 名男性接受了膝关节和 80 名男性接受了髋关节 OA 关节置换，随访时间为 10.7（SD 3.8）年。超重和肥胖男性中，较高的雄烯二酮浓度与全膝关节（风险比（HR）0.87，95%置信区间（CI）0.77-0.98）和髋关节（HR 0.84 95% CI 0.71-1.00）OA 关节置换的风险降低相关。对于其他测量的激素，未观察到显著相关性。
低血浆雄烯二酮浓度与超重和肥胖男性膝关节和髋关节 OA 关节置换的风险增加有关。虽然这些发现需要在其他队列研究中得到证实，但它们表明循环性激素可能在男性 OA 的发病机制中发挥作用。
