含吡啶环的1-金刚烷甲酰腙铜（II）配合物的合成、表征、细胞毒性及抗血管生成活性
Synthesis, characterization, cytotoxicity and antiangiogenic activity of copper(II) complexes with 1-adamantoyl hydrazone bearing pyridine rings.
作者信息
Rodić Marko V, Leovac Vukadin M, Jovanović Ljiljana S, Spasojević Vojislav, Joksović Milan D, Stanojković Tatjana, Matić Ivana Z, Vojinović-Ješić Ljiljana S, Marković Violeta
机构信息
University of Novi Sad, Faculty of Sciences, Trg D. Obradovića 3, 21000, Novi Sad, Serbia.
University of Novi Sad, Faculty of Sciences, Trg D. Obradovića 3, 21000, Novi Sad, Serbia.
出版信息
Eur J Med Chem. 2016 Jun 10;115:75-81. doi: 10.1016/j.ejmech.2016.03.003. Epub 2016 Mar 8.
Three novel copper complexes with tridentate N2O ligand di(2-pyridil) ketone 1-adamantoyl hydrazone (Addpy) of the formula [Cu(II)2Cu(I)2(Addpy)2Br2(μ-Br4)] (1), catena-poly[CuCl(μ-Addpy)(μ-Cl)CuCl2]n (2) and [Cu(Addpy)(NCS)2] (3) were synthesized. Complexes are characterized by X-ray crystallography, spectral (UV-Vis, FTIR), electrochemical (CV) analyses, and magnetochemical measurements. Investigation of anticancer potential of Cu(II) complexes, mode of cell death, apoptosis, and inhibition of angiogenesis were performed. All tested malignant cell lines (HeLa, LS174, A549, K562, and MDA-MB-231) showed high sensitivity to the examined Cu(II) complexes. It has been shown that the complexes induce apoptosis in the caspase 3-dependent manner, whereas the anti-angiogenic effects of 1, 2, and 3 have been confirmed in EA.hy926 cells using a tube formation assay.
合成了三种新型铜配合物，其配体为具有三齿N2O的二（2-吡啶基）酮1-金刚烷酰腙（Addpy），化学式分别为[Cu(II)2Cu(I)2(Addpy)2Br2(μ-Br4)] (1)、链状聚[CuCl(μ-Addpy)(μ-Cl)CuCl2]n (2) 和 [Cu(Addpy)(NCS)2] (3)。通过X射线晶体学、光谱（紫外可见光谱、傅里叶变换红外光谱）、电化学（循环伏安法）分析以及磁化学测量对配合物进行了表征。对铜（II）配合物的抗癌潜力、细胞死亡模式、凋亡以及血管生成抑制进行了研究。所有测试的恶性细胞系（HeLa、LS174、A549、K562和MDA-MB-231）对所检测的铜（II）配合物均表现出高度敏感性。结果表明，这些配合物以半胱天冬酶3依赖性方式诱导细胞凋亡，而通过管形成试验在EA.hy926细胞中证实了配合物1、2和3的抗血管生成作用。
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