新型色酮腙金属配合物对 HCT116、MCF7 和 HELA 肿瘤细胞系的抗增殖作用。
Antiproliferative effects of metal complexes of new isatin hydrazones against HCT116, MCF7 and HELA tumour cell lines.
机构信息
Department of Chemistry, Faculty of Women, Ain Shams University, Heliopolis, Cairo, Egypt.
出版信息
J Enzyme Inhib Med Chem. 2012 Jun;27(3):330-8. doi: 10.3109/14756366.2011.588950. Epub 2011 Jun 24.
New hydrazone ligands (HL) derived from 5-substituted isatins and 1-(4-(2-methoxybenzyl)-6-arylpyridazin-3-yl)hydrazines and its complexes with Co(II) and Cu(II) were synthesized. The new hydrazones and their complexes were characterized by means of elemental, spectral analyses and magnetic studies. Primary cytotoxicity evaluation of HL 5a and the new complexes showed that these complexes could act as anticancer agents since they reduced the growth of samples of human tumour cell lines (HCT116((Colon)), MCF7((Breast)) and HELA((Cervix))) to ≤18.5 μg/mL for the new complexes.
合成了新的腙配体（HL），其来源于 5-取代的色酮和 1-（4-（2-甲氧基苄基）-6-芳基哒嗪-3-基）肼，并研究了其与 Co(II)和 Cu(II)的配合物。通过元素分析、光谱分析和磁性研究对新的腙及其配合物进行了表征。HL5a 和新配合物的初步细胞毒性评价表明，这些配合物可以作为抗癌剂，因为它们将人肿瘤细胞系（HCT116（结肠）、MCF7（乳腺）和 HELA（宫颈））的生长降低到≤新配合物的 18.5μg/mL。
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