Li Lanfang, Xu Jin, He Lu, Peng Lijun, Zhong Qiaoqing, Chen Linxi, Jiang Zhisheng
Post-Doctoral Mobile Stations for Basic Medicine, Institute of Cardiovascular Disease, Key Laboratory for Arteriosclerology of Hunan Province, University of South China, Hengyang 421001, China Hunan Children's Hospital and School of Pediatrics, University of South China, Changsha 410007, China.
Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study, Institute of Pharmacy and Pharmacology, Learning Key Laboratory for Pharmacoproteomics, University of South China, Hengyang 421001, China.
Acta Biochim Biophys Sin (Shanghai). 2016 Jun;48(6):491-500. doi: 10.1093/abbs/gmw025. Epub 2016 Apr 15.
Autophagy is conserved in nature from lower eukaryotes to mammals and is an important self-cannibalizing, degradative process that contributes to the elimination of superfluous materials. Cardiac hypertrophy is primarily characterized by excess protein synthesis, increased cardiomyocyte size, and thickened ventricular walls and is a major risk factor that promotes arrhythmia and heart failure. In recent years, cardiomyocyte autophagy has been considered to play a role in controlling the hypertrophic response. However, the beneficial or aggravating role of cardiomyocyte autophagy in cardiac hypertrophy remains controversial. The exact mechanism of cardiomyocyte autophagy in cardiac hypertrophy requires further study. In this review, we summarize the controversies associated with autophagy in cardiac hypertrophy and provide insights into the role of autophagy in the development of cardiac hypertrophy. We conclude that future studies should emphasize the relationship between autophagy and the different stages of cardiac hypertrophy, as well as the autophagic flux and selective autophagy. Autophagy will be a potential therapeutic target for cardiac hypertrophy.
自噬在从低等真核生物到哺乳动物的自然界中是保守的，是一个重要的自我吞噬、降解过程，有助于清除多余物质。心脏肥大的主要特征是蛋白质合成过多、心肌细胞大小增加和心室壁增厚，是促进心律失常和心力衰竭的主要危险因素。近年来，心肌细胞自噬被认为在控制肥大反应中起作用。然而，心肌细胞自噬在心脏肥大中的有益或加重作用仍存在争议。心肌细胞自噬在心脏肥大的确切机制需要进一步研究。在本综述中，我们总结了与心脏肥大中自噬相关的争议，并深入探讨了自噬在心脏肥大发展中的作用。我们得出结论，未来的研究应强调自噬与心脏肥大不同阶段之间的关系，以及自噬通量和选择性自噬。自噬将是心脏肥大的一个潜在治疗靶点。
