Huang He, Yang Jun, Luciano Mark, Shriver Leah P
Departments of Chemistry and Biology, University of Akron, Akron, OH, 44325, USA.
Department of Neurological Surgery, Section of Pediatric and Congenital Neurological Surgery, CSF Physiology Laboratory, Neurological Institute Cleveland Clinic, Cleveland, OH, 44106, USA.
Neurochem Res. 2016 Jul;41(7):1713-22. doi: 10.1007/s11064-016-1887-z. Epub 2016 Apr 15.
Idiopathic normal pressure hydrocephalus is a neurological disease caused by abnormal cerebrospinal fluid flow and presents with symptoms such as dementia. Current therapy involves the removal of excess cerebrospinal fluid by shunting. Not all patients respond to this therapy and biomarkers are needed that could facilitate the characterization of patients likely to benefit from this treatment. Here, we measure brain metabolism in normal pressure hydrocephalus patients by performing a novel longitudinal metabolomic profiling study of cerebrospinal fluid. We find that the levels of brain metabolites correlate with clinical parameters, the amount of vascular endothelial growth factor in the cerebrospinal fluid, and environmental stimuli such as exercise. Metabolomic analysis of normal pressure hydrocephalus patients provides insight into changes in brain metabolism that accompany cerebrospinal fluid disorders and may facilitate the development of new biomarkers for this condition.
特发性正常压力脑积水是一种由脑脊液流动异常引起的神经疾病，表现为痴呆等症状。目前的治疗方法是通过分流来清除多余的脑脊液。并非所有患者对这种治疗都有反应，因此需要生物标志物来帮助确定可能从该治疗中获益的患者特征。在此，我们通过对脑脊液进行一项新颖的纵向代谢组学分析研究，来测量正常压力脑积水患者的脑代谢。我们发现脑代谢物水平与临床参数、脑脊液中血管内皮生长因子的含量以及运动等环境刺激因素相关。对正常压力脑积水患者的代谢组学分析有助于深入了解伴随脑脊液紊乱的脑代谢变化，并可能促进针对这种疾病的新生物标志物的开发。
