Madon E, Cordero di Montezemolo L, Pastore G
Tumori. 1977 Jul-Aug;63(4):367-72. doi: 10.1177/030089167706300408.
The influence on the duration of CR and survival of 2 modalities (MTX + hydrocortisone IT, with and without TCT) for the prevention of meningeal CNS involvement was assessed in 24 children with acute lymphoblastic leukemia. Of the 9 subjects who received MTX and hydrocortisone only, 42% were still in CR 33 months after its attainment, as opposed to 75% of the 15 who also received TCT. Survival at 33 months after diagnosis was 89% and 82% in the 2 groups. The results are compared with those obtained in an earlier series of 14 children who received no prophylactic treatment. Here CR at 45 months was 25% and survival 46%. Eight subjects died, as opposed to 3 (1 in CR) in the present series.
在24例急性淋巴细胞白血病患儿中，评估了两种预防脑膜中枢神经系统受累的方式（甲氨蝶呤+氢化可的松鞘内注射，有或无TCT）对完全缓解（CR）持续时间和生存率的影响。仅接受甲氨蝶呤和氢化可的松的9名受试者中，42%在达到CR后33个月仍处于CR状态，而在同时接受TCT的15名受试者中这一比例为75%。两组在诊断后33个月的生存率分别为89%和82%。将这些结果与早期一组14例未接受预防性治疗的患儿的结果进行比较。在那组中，45个月时的CR率为25%，生存率为46%。有8名受试者死亡，而在本系列中为3名（1名处于CR状态）。
