van den Tempel Nathalie, Horsman Michael R, Kanaar Roland
a Department of Molecular Genetics, Cancer Genomic Netherlands, Department of Radiation Oncology , Erasmus Medical Centre , Rotterdam , the Netherlands ;
b Department of Experimental Clinical Oncology , Aarhus University Hospital , Aarhus , Denmark.
Int J Hyperthermia. 2016 Jun;32(4):446-54. doi: 10.3109/02656736.2016.1157216. Epub 2016 Apr 18.
It has long been established that hyperthermia increases the therapeutic benefit of radiation and chemotherapy in cancer treatment. During the last few years there have been substantial technical improvements in the sources used to apply and measure heat, which greatly increases enthusiasm for the clinical use of hyperthermia. These advances are converging with a better understanding of the physiological and molecular effects of hyperthermia. Therefore, we are now at a juncture where the parameters that will influence the efficacy of hyperthermia in cancer treatment can be optimised in a more systematic and rational manner. In addition, the novel insights in hyperthermia's many biological effects on tumour cells will ultimately result in new treatment regimes. For example, the molecular effects of hyperthermia on the essential cellular process of DNA repair suggest novel combination therapies, with DNA damage response targeting drugs that should now be clinically explored. Here, we provide an overview of recent studies on the various macroscopic and microscopic biological effects of hyperthermia. We indicate the significance of these effects on current treatments and suggest how they will help design novel future treatments.
长期以来，人们已经确定热疗可提高放疗和化疗在癌症治疗中的疗效。在过去几年中，用于施加和测量热量的设备有了实质性的技术改进，这极大地增强了人们对热疗临床应用的热情。这些进展与对热疗的生理和分子效应的更深入理解相结合。因此，我们现在正处于一个关键节点，在此可以更系统、合理地优化影响热疗在癌症治疗中疗效的参数。此外，热疗对肿瘤细胞多种生物学效应的新见解最终将导致新的治疗方案。例如，热疗对DNA修复这一基本细胞过程的分子效应提示了新的联合治疗方法，即现在应该在临床上探索靶向DNA损伤反应的药物。在此，我们概述了关于热疗各种宏观和微观生物学效应的近期研究。我们指出了这些效应在当前治疗中的重要性，并提出它们将如何有助于设计未来的新型治疗方法。
