Scotti Luciana, Singla Rajeev Kumar, Ishiki Hamilton Mitsugu, Mendonca Francisco Jaime B, da Silva Marcelo Sobral, Barbosa Filho José Maria, Scotti Marcus Tullius
Health Sciences Center, Federal University of Paraíba, Campus I, 58051-970, João Pessoa-PB, Brazil.
Curr Top Med Chem. 2016;16(23):2525-31. doi: 10.2174/1568026616666160414123857.
The use of natural products for the treatment of disease is one of the oldest cultures exists. Currently, the research of new drugs using natural products shows a poorly explored biodiversity and a great interest of marketing. The enzymatic inhibition by some natural products is investigated among these is the inhibition of hyaluronidase and the consequent reduction of the degradation of hyaluronic acid. So there is a reduction of inflammation and angiogenesis. This study reports the main natural species studied in inhibiting human hyaluronidase that can be the subject of future research for new drugs.
使用天然产物治疗疾病是现存最古老的文化之一。目前，利用天然产物研发新药展现出生物多样性探索不足但具有巨大的市场潜力。在这些研究中，对一些天然产物的酶抑制作用进行了研究，其中包括对透明质酸酶的抑制以及随之而来的透明质酸降解减少。这样就会减轻炎症和血管生成。本研究报告了在抑制人透明质酸酶方面所研究的主要天然物种，这些物种可能成为未来新药研究的对象。
