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一项关于药剂师参与对马来西亚糖尿病药物治疗依从性项目结果影响的研究。

Study investigating the impact of pharmacist involvement on the outcomes of diabetes medication therapy adherence program Malaysia.

作者信息

Lim Phei Ching, Lim Kelvin, Embee Zubaidah Che, Hassali Mohamed Azmi, Thiagarajan Anuradha, Khan Tahir Mehmood

机构信息

Pharmacy Department, Pulau Pinang Hospital, Jalan Residensi, Penang, Malaysia.

Discipline of Social and Administrative Pharmacy, School of Pharmaceutical Sciences, University Sains Malaysia, Malaysia.

出版信息

Pak J Pharm Sci. 2016 Mar;29(2):595-601.

Abstract

Involvement of pharmacists in improving medication adherence among diabetic patients is recognized globally. In Malaysian healthcare system, pharmacists are also operating health services i.e. Diabetes Medication Therapy Adherence Clinic (DMTAC). This study aimed to assess the clinical outcomes of patients managed by pharmacists (DMTAC), in a Malaysian hospital setting. This was an open labelled randomised study. Type 2 diabetes patients with HbA1c ≥8% were recruited and arbitrarily divided into the intervention group (usual care plus DMTAC) and the non-intervention group (usual care only). Those enrolled in the intervention group were scheduled for follow-up for eight consecutive visits. Improvements in lab results were compared longitudinally (pre and post analysis) between the groups. Data analysis was done using PASW 18® version. A total of 76 patients were enrolled, with 39 patients in the intervention group and 37 patients in the non-intervention group. Mean HbA1c (-0.90% vs. -0.08%, p=0.011) and fasting blood glucose levels (-3.45 mmol.l vs. +0.79 mmol/l, p=0.002) reduced significantly between the intervention group vs. non-intervention group. Total cholesterol and low-density lipoprotein cholesterol (LDL-C) were also significantly reduced in the intervention group (TC -0.34 mmol/l, p=0.018) (LDL -0.45 mmol/l, p=0.001). In conclusion, pharmacists managed DMTAC significantly improved glycaemic control and lipid profile of diabetic patients.

摘要

药剂师参与改善糖尿病患者的用药依从性在全球范围内得到认可。在马来西亚的医疗保健系统中,药剂师也在提供健康服务,即糖尿病药物治疗依从性诊所(DMTAC)。本研究旨在评估在马来西亚医院环境中由药剂师管理的患者(DMTAC)的临床结局。这是一项开放标签随机研究。招募糖化血红蛋白(HbA1c)≥8%的2型糖尿病患者,并将其随机分为干预组(常规护理加DMTAC)和非干预组(仅常规护理)。干预组的患者安排连续随访8次。纵向比较两组之间实验室结果的改善情况(分析前后)。使用PASW 18®版本进行数据分析。共招募了76名患者,干预组39名患者,非干预组37名患者。干预组与非干预组之间,糖化血红蛋白平均水平(-0.90%对-0.08%,p = 0.011)和空腹血糖水平(-3.45 mmol/l对+0.79 mmol/l,p = 0.002)显著降低。干预组的总胆固醇和低密度脂蛋白胆固醇(LDL-C)也显著降低(总胆固醇-0.34 mmol/l,p = 0.018)(低密度脂蛋白-0.45 mmol/l,p = 0.001)。总之,药剂师管理的DMTAC显著改善了糖尿病患者的血糖控制和血脂状况。

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