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[精准医学:分子流行病学的新机遇与挑战]

[Precision medicine: new opportunities and challenges for molecular epidemiology].

作者信息

Song Jing, Hu Yonghua

机构信息

Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing 100191, China.

出版信息

Zhonghua Liu Xing Bing Xue Za Zhi. 2016 Apr;37(4):587-92. doi: 10.3760/cma.j.issn.0254-6450.2016.04.030.

Abstract

Since the completion of the Human Genome Project in 2003 and the announcement of the Precision Medicine Initiative by U.S. President Barack Obama in January 2015, human beings have initially completed the " three steps" of " genomics to biology, genomics to health as well as genomics to society". As a new inter-discipline, the emergence and development of precision medicine have relied on the support and promotion from biological science, basic medicine, clinical medicine, epidemiology, statistics, sociology and information science, etc. Meanwhile, molecular epidemiology is considered to be the core power to promote precision medical as a cross discipline of epidemiology and molecular biology. This article is based on the characteristics and research progress of medicine and molecular epidemiology respectively, focusing on the contribution and significance of molecular epidemiology to precision medicine, and exploring the possible opportunities and challenges in the future.

摘要

自2003年人类基因组计划完成以及2015年1月美国总统巴拉克·奥巴马宣布精准医学计划以来,人类初步完成了“基因组学向生物学、基因组学向健康以及基因组学向社会”的“三步走”。作为一门新兴的交叉学科,精准医学的出现和发展依赖于生物科学、基础医学、临床医学、流行病学、统计学、社会学和信息科学等学科的支持与推动。同时,分子流行病学作为流行病学与分子生物学的交叉学科,被认为是推动精准医学的核心力量。本文分别基于医学和分子流行病学的特点及研究进展,着重探讨分子流行病学对精准医学的贡献和意义,并探寻未来可能面临的机遇与挑战。

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