Pelgrim G J, Handayani A, Dijkstra H, Prakken N H J, Slart R H J A, Oudkerk M, Van Ooijen P M A, Vliegenthart R, Sijens P E
University Medical Center Groningen, Center for Medical Imaging North-East Netherlands (CMI-NEN), University of Groningen, Hanzeplein 1, 9713 GZ Groningen, Netherlands; University Medical Center Groningen, Department of Radiology, University of Groningen, Hanzeplein 1, 9713 GZ Groningen, Netherlands.
University Medical Center Groningen, Center for Medical Imaging North-East Netherlands (CMI-NEN), University of Groningen, Hanzeplein 1, 9713 GZ Groningen, Netherlands; University Medical Center Groningen, Department of Nuclear Medicine and Molecular Imaging, University of Groningen, Hanzeplein 1, 9713 GZ Groningen, Netherlands.
Biomed Res Int. 2016;2016:1734190. doi: 10.1155/2016/1734190. Epub 2016 Mar 10.
Technological advances in magnetic resonance imaging (MRI) and computed tomography (CT), including higher spatial and temporal resolution, have made the prospect of performing absolute myocardial perfusion quantification possible, previously only achievable with positron emission tomography (PET). This could facilitate integration of myocardial perfusion biomarkers into the current workup for coronary artery disease (CAD), as MRI and CT systems are more widely available than PET scanners. Cardiac PET scanning remains expensive and is restricted by the requirement of a nearby cyclotron. Clinical evidence is needed to demonstrate that MRI and CT have similar accuracy for myocardial perfusion quantification as PET. However, lack of standardization of acquisition protocols and tracer kinetic model selection complicates comparison between different studies and modalities. The aim of this overview is to provide insight into the different tracer kinetic models for quantitative myocardial perfusion analysis and to address typical implementation issues in MRI and CT. We compare different models based on their theoretical derivations and present the respective consequences for MRI and CT acquisition parameters, highlighting the interplay between tracer kinetic modeling and acquisition settings.
磁共振成像（MRI）和计算机断层扫描（CT）技术的进步，包括更高的空间和时间分辨率，使得进行绝对心肌灌注定量成为可能，而这在以前只有通过正电子发射断层扫描（PET）才能实现。由于MRI和CT系统比PET扫描仪更广泛可得，这可能有助于将心肌灌注生物标志物纳入当前冠状动脉疾病（CAD）的检查流程中。心脏PET扫描仍然昂贵，并且受到附近需要回旋加速器的限制。需要临床证据来证明MRI和CT在心肌灌注定量方面具有与PET相似的准确性。然而，采集协议和示踪剂动力学模型选择缺乏标准化，使得不同研究和模式之间的比较变得复杂。本综述的目的是深入了解用于定量心肌灌注分析的不同示踪剂动力学模型，并解决MRI和CT中的典型实施问题。我们根据不同模型的理论推导进行比较，并阐述它们对MRI和CT采集参数的各自影响，突出示踪剂动力学建模与采集设置之间的相互作用。
