Department of Energy and Hydrocarbon Chemistry, Graduate School of Engineering, Kyoto University , Nishikyo-ku, Kyoto 615-8510, Japan.
J Am Chem Soc. 2016 May 4;138(17):5547-50. doi: 10.1021/jacs.6b02961. Epub 2016 Apr 22.
Cobalt-catalyzed carboxyzincation reactions employing carbon dioxide and zinc metal powder are developed. By using alkynes as substrates, regio- and stereodefined (Z)-β-zincated acrylates are provided. The corresponding alkenylzinc moiety can be converted to various substituents, affording multisubstituted acrylic acids. Furthermore, by adding electron-deficient alkene to the reaction system, the four-component coupling reactions of alkyne, alkene, CO2, and the Zn atom proceed via carboxyzincation.
发展了钴催化的二氧化碳和锌粉参与的羧锌化反应。以炔烃作为底物，提供了区域和立体选择性的（Z）-β-锌化丙烯酸盐。相应的烯基锌部分可以转化为各种取代基，得到多取代丙烯酸。此外，通过向反应体系中添加缺电子烯烃，炔烃、烯烃、CO2 和 Zn 原子的四组分偶联反应通过羧锌化进行。
