胰岛素抵抗与颈动脉内膜中层厚度介导静息态心率变异性与执行功能之间的关联：一项路径建模研究。
Insulin resistance and carotid intima-media thickness mediate the association between resting-state heart rate variability and executive function: A path modelling study.
作者信息
Kemp Andrew H, López Santiago Rodríguez, Passos Valeria M A, Bittencourt Marcio S, Dantas Eduardo M, Mill José G, Ribeiro Antonio L P, Thayer Julian F, Bensenor Isabela M, Lotufo Paulo A
机构信息
University Hospital and Faculty of Medicine, University of São Paulo, São Paulo, Brazil; School of Psychology & Discipline of Psychiatry, University of Sydney, Sydney, Australia.
University Hospital and Faculty of Medicine, University of São Paulo, São Paulo, Brazil; Department of Biology, Universidad Autónoma de Madrid, Spain.
出版信息
Biol Psychol. 2016 May;117:216-224. doi: 10.1016/j.biopsycho.2016.04.006. Epub 2016 Apr 14.
BACKGROUND
Research has linked high-frequency heart rate variability (HF-HRV) to cognitive function. The present study adopts a modern path modelling approach to understand potential causal pathways that may underpin this relationship.
METHODS
Here we examine the association between resting-state HF-HRV and executive function in a large sample of civil servants from Brazil (N=8114) recruited for the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil). HF-HRV was calculated from 10-min resting-state electrocardiograms. Executive function was assessed using the trail-making test (version B).
RESULTS AND CONCLUSIONS
Insulin resistance (a marker of type 2 diabetes mellitus) and carotid intima-media thickness (subclinical atherosclerosis) mediated the relationship between HRV and executive function in seriatim. A limitation of the present study is its cross-sectional design; therefore, conclusions must be confirmed in longitudinal study. Nevertheless, findings support that possibility that HRV provides a 'spark' that initiates a cascade of adverse downstream effects that subsequently leads to cognitive impairment.
背景
研究已将高频心率变异性（HF-HRV）与认知功能联系起来。本研究采用现代路径建模方法来理解可能支撑这种关系的潜在因果途径。
方法
我们在此研究巴西成人健康纵向研究（ELSA-Brasil）招募的大量巴西公务员（N = 8114）静息状态下的HF-HRV与执行功能之间的关联。HF-HRV由10分钟静息状态心电图计算得出。执行功能使用连线测验（B版）进行评估。
结果与结论
胰岛素抵抗（2型糖尿病的一个标志物）和颈动脉内膜中层厚度（亚临床动脉粥样硬化）依次介导了HRV与执行功能之间的关系。本研究的一个局限性是其横断面设计；因此，结论必须在纵向研究中得到证实。尽管如此，研究结果支持HRV提供一个“触发因素”，引发一系列不良下游效应，随后导致认知障碍的可能性。
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