Wang Wei, Cui Shan-Shan, Lu Rui, Zhang Hui
State Key Laboratory of Military Stomatology, Department of Anesthesiology, School of Stomatology, the Fourth Military Medical University, Xi'an 710032, China.
Department of Anesthesiology, Zhongnan Hospital, Wuhan University, East Lake Road, Wuhan 430071, China.
Brain Res Bull. 2016 Jul;125:44-52. doi: 10.1016/j.brainresbull.2016.04.010. Epub 2016 Apr 22.
Chronic pain is a complex clinical condition that reduces the quality of life for billions of people. In recent years, the role of epigenetic modulation in the control of long-term neuronal plasticity has attracted the attention of pain researchers. The epigenetic mechanisms include covalent modifications of DNA and/or histone proteins. Mounting evidence suggests that the activity of histone deacetylases (HDACs) and levels of histone acetylation are dynamic and that these enzymes modulate pain-related synaptic plasticity. Therefore, HDACs play essential roles in chronic pain development and maintenance. In this mini review, we will discuss the role of HDACs in the pathogenesis of chronic pain and will consider the therapeutic value of HDAC inhibitors in treating chronic pain.
慢性疼痛是一种复杂的临床病症，降低了数十亿人的生活质量。近年来，表观遗传调控在长期神经元可塑性控制中的作用引起了疼痛研究人员的关注。表观遗传机制包括DNA和/或组蛋白的共价修饰。越来越多的证据表明，组蛋白脱乙酰酶（HDACs）的活性和组蛋白乙酰化水平是动态变化的，并且这些酶调节与疼痛相关的突触可塑性。因此，HDACs在慢性疼痛的发生和维持中起着至关重要的作用。在本综述中，我们将讨论HDACs在慢性疼痛发病机制中的作用，并探讨HDAC抑制剂在治疗慢性疼痛方面的治疗价值。
