School of Basic Medical Sciences, Xinxiang Medical University, Xinxiang, Henan, China.
Key Laboratory for Molecular Neurology of Xinxiang, Xinxiang, Henan, China.
Curr Neuropharmacol. 2024;22(2):191-203. doi: 10.2174/1570159X20666220927092016.
The intestinal homeostasis maintained by the gut microbiome and relevant metabolites is essential for health, and its disturbance leads to various intestinal or extraintestinal diseases. Recent studies suggest that gut microbiome-derived metabolites short-chain fatty acids (SCFAs) are involved in different neurological disorders (such as chronic pain). SCFAs are produced by bacterial fermentation of dietary fibers in the gut and contribute to multiple host processes, including gastrointestinal regulation, cardiovascular modulation, and neuroendocrine-immune homeostasis. Although SCFAs have been implicated in the modulation of chronic pain, the detailed mechanisms that underlie such roles of SCFAs remain to be further investigated. In this review, we summarize currently available research data regarding SCFAs as a potential therapeutic target for chronic pain treatment and discuss several possible mechanisms by which SCFAs modulate chronic pain.
肠道微生物组和相关代谢物维持的肠道内稳态对健康至关重要，其紊乱会导致各种肠道或肠道外疾病。最近的研究表明，肠道微生物组衍生的代谢物短链脂肪酸（SCFAs）参与了不同的神经疾病（如慢性疼痛）。SCFAs 是肠道细菌对膳食纤维发酵产生的，有助于多种宿主过程，包括胃肠道调节、心血管调节和神经内分泌-免疫稳态。尽管 SCFAs 已被证明可以调节慢性疼痛，但 SCFAs 发挥作用的详细机制仍有待进一步研究。在这篇综述中，我们总结了目前关于 SCFAs 作为慢性疼痛治疗潜在治疗靶点的研究数据，并讨论了 SCFAs 调节慢性疼痛的几种可能机制。
