Wang Yaoling, Yue Qiming, Zhao Yi, Qiu Shubing, Peng Yao, Li Jue, Zhang Tao, Hai Li, Guo Li, Wu Yong
Key Laboratory of Drug Targeting and Drug Delivery Systems, West China School of Pharmacy, Sichuan University, Chengdu 610041, PR China.
ChengDu Military General Hospital, Chengdu 610083, PR China.
Steroids. 2016 Jun;110:70-76. doi: 10.1016/j.steroids.2016.04.004. Epub 2016 Apr 23.
In this study, we report the first synthesis of 22-oxa-chenodeoxycholic acid analogue via androstenedione and progesterone, in 11 and 8 steps with overall yields of 6.4% and 12.7%, respectively. We anticipate this will help to facilitate the development of new drugs.
