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对有望用于甾体修饰的子囊菌sp. VKM F-3040进行转录组组装。

transcriptome assembly of sp. VKM F-3040, a promising steroid-modifying ascomycete.

作者信息

Kollerov Vyacheslav V, Tarlachkov Sergey V, Donova Marina V

机构信息

G.K. Skryabin Institute of Biochemistry and Physiology of Microorganisms, Federal Research Center "Pushchino Center for Biological Research" of Russian Academy of Sciences Prospekt Nauki , Pushchino, Moscow region, Russia.

出版信息

Microbiol Resour Announc. 2023 Nov 16;12(11):e0066323. doi: 10.1128/MRA.00663-23. Epub 2023 Oct 11.

DOI:10.1128/MRA.00663-23
PMID:37819136
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10652950/
Abstract

This research presents transcriptome shotgun assembly for sp. VKM F-3040, which is a putative fungal strain able to modify androstane steroids with production of 7-hydroxy and 17-hydroxylated derivatives-key intermediates in the synthesis of pharmaceutical ingredients. The data are of importance for creating novel microbial biocatalysts.

摘要

本研究展示了对菌株VKM F-3040的转录组鸟枪法测序组装结果，该菌株被认为是一种能够修饰雄甾烷类固醇并产生7-羟基和17-羟基化衍生物的真菌菌株，这些衍生物是药物成分合成中的关键中间体。这些数据对于创建新型微生物生物催化剂具有重要意义。

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本文引用的文献

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Steroid modification by filamentous fungus Drechslera sp.: Focus on 7-hydroxylase and 17β-hydroxysteroid dehydrogenase activities.丝状真菌 Drechslera sp. 的甾体修饰：关注 7-羟化酶和 17β-羟甾脱氢酶活性。
Fungal Biol. 2022 Jan;126(1):91-100. doi: 10.1016/j.funbio.2021.11.002. Epub 2021 Nov 3.
2
Biotransformation of androstenedione and androstadienedione by selected Ascomycota and Zygomycota fungal strains.某些子囊菌和接合菌真菌菌株对雄烯二酮和雄甾烯二酮的生物转化。
Phytochemistry. 2020 Jan;169:112160. doi: 10.1016/j.phytochem.2019.112160. Epub 2019 Oct 7.
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First synthesis of 22-oxa-chenodeoxycholic acid analogue.
Steroids. 2016 Jun;110:70-76. doi: 10.1016/j.steroids.2016.04.004. Epub 2016 Apr 23.
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Trimmomatic: a flexible trimmer for Illumina sequence data.Trimmomatic：一款适用于 Illumina 测序数据的灵活修剪工具。
Bioinformatics. 2014 Aug 1;30(15):2114-20. doi: 10.1093/bioinformatics/btu170. Epub 2014 Apr 1.
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Full-length transcriptome assembly from RNA-Seq data without a reference genome.无参考基因组的 RNA-Seq 数据的全长转录组组装。
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