Ebajemito James K, Furlan Leonardo, Nissen Christoph, Sterr Annette
School of Psychology, Faculty of Health and Medical Sciences, University of Surrey , Guildford , UK.
Department of Psychiatry and Psychotherapy, University of Freiburg Medical Center , Freiburg , Germany.
Front Neurol. 2016 Apr 6;7:54. doi: 10.3389/fneur.2016.00054. eCollection 2016.
The relationship between sleep disorders and neurological disorders is often reciprocal, such that sleep disorders are worsened by neurological symptoms and that neurological disorders are aggravated by poor sleep. Animal and human studies further suggest that sleep disruption not only worsens single neurological symptoms but may also lead to long-term negative outcomes. This suggests that sleep may play a fundamental role in neurorehabilitation and recovery. We further propose that sleep may not only alter the efficacy of behavioral treatments but also plasticity-enhancing adjunctive neurostimulation methods, such as transcranial direct current stimulation (tDCS). At present, sleep receives little attention in the fields of neurorehabilitation and neurostimulation. In this review, we draw together the strands of evidence from both fields of research to highlight the proposition that sleep is an important parameter to consider in the application of tDCS as a primary or adjunct rehabilitation intervention.
睡眠障碍与神经疾病之间的关系往往是相互的，即神经症状会使睡眠障碍恶化，而睡眠不佳会加重神经疾病。动物和人体研究进一步表明，睡眠中断不仅会使单一神经症状恶化，还可能导致长期的负面后果。这表明睡眠可能在神经康复和恢复中发挥着根本性作用。我们进一步提出，睡眠不仅可能改变行为治疗的效果，还可能影响增强可塑性的辅助神经刺激方法，如经颅直流电刺激（tDCS）。目前，在神经康复和神经刺激领域，睡眠很少受到关注。在这篇综述中，我们汇集了来自这两个研究领域的证据，以强调睡眠是在将tDCS作为主要或辅助康复干预措施应用时需要考虑的一个重要参数这一观点。
