神经系统发育中的Eph-ephrin信号传导
Eph-ephrin signaling in nervous system development.
作者信息
Cramer Karina S, Miko Ilona J
机构信息
Department of Neurobiology and Behavior, University of California, Irvine, Irvine, CA, USA.
出版信息
F1000Res. 2016 Mar 30;5. doi: 10.12688/f1000research.7417.1. eCollection 2016.
Abstract
Ephrins and Eph receptors enable contact-mediated interactions between cells at every stage of nervous system development. In spite of their broad binding affinities, Eph proteins facilitate specificity in neuronal migration and axon targeting. This review focuses on recent studies that demonstrate how these proteins interact with each other, and with other signaling pathways, to guide specificity in a diverse set of developmental processes.
摘要
在神经系统发育的每个阶段，Ephrin 蛋白和 Eph 受体都能使细胞间实现接触介导的相互作用。尽管 Eph 蛋白具有广泛的结合亲和力，但它们在神经元迁移和轴突靶向中促进了特异性。本综述聚焦于近期的研究，这些研究展示了这些蛋白如何相互作用，以及如何与其他信号通路相互作用，从而在一系列不同的发育过程中引导特异性。
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