Ueda-Iuchi Terumi, Ohno Naoki, Miyati Tosiaki, Dai Misako, Okuwa Mayumi, Nakatani Toshio, Sanada Hiromi, Sugama Junko
Division of Health Sciences, Graduate School of Medical Sciences, Kanazawa University, Kanazawa, Japan.
Faculty of Health Sciences, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa, Japan; Wellness Promotion Science Center, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa, Japan.
SAGE Open Med. 2015 Nov 2;3:2050312115613351. doi: 10.1177/2050312115613351. eCollection 2015.
Lymphoedema involves swelling, especially in the subcutaneous tissues. For lymphoedema management to be successful, it is necessary to remove the interstitial fluid. Subcutaneous echogenicity may be associated with interstitial fluid, but echogenicity is not an indicator for the evaluation of management because we do not directly compare echogenicity with the interstitial fluid. We aimed to identify an outcome indicator for the evaluation of interstitial fluid using ultrasonography. We assessed the correlation between echogenicity and transverse relaxation rate (R2) on magnetic resonance imaging.
This was an observational study. Healthy adults with leg swelling after activity for >8 h were recruited. The legs of 13 women were evaluated using ultrasonography, magnetic resonance imaging and measurements of the limb circumference before and after an intervention to reduce the swelling.
Echogenicity in the oedema group was greater than that of the controls. Echogenicity decreased with reductions in oedema. The range of the strongest correlations with the changes in R2 occurred at echogenicity values of 48-144 (Pearson's correlation coefficient: r = -0.63 and p < 0.01). Thus, it was possible to evaluate the interstitial fluid using echogenicity.
The outcome indicators for the evaluation of interstitial fluid using ultrasonography were echogenicities in the range of 48-144, and these values were valid for assessing the interstitial fluid in the subcutaneous tissue.
淋巴水肿会导致肿胀，尤其是皮下组织肿胀。要成功管理淋巴水肿，有必要清除组织间液。皮下组织回声可能与组织间液有关，但回声不是评估治疗效果的指标，因为我们没有直接将回声与组织间液进行比较。我们旨在确定一种使用超声评估组织间液的结局指标。我们评估了磁共振成像上回声与横向弛豫率（R2）之间的相关性。
这是一项观察性研究。招募了活动8小时以上后腿部肿胀的健康成年人。在进行减轻肿胀的干预前后，对13名女性的腿部进行了超声、磁共振成像检查以及肢体周长测量。
水肿组的回声高于对照组。回声随着水肿减轻而降低。与R2变化相关性最强的范围出现在回声值为48 - 144时（皮尔逊相关系数：r = -0.63，p < 0.01）。因此，有可能利用回声评估组织间液。
使用超声评估组织间液的结局指标是48 - 144范围内的回声，这些值对于评估皮下组织中的组织间液是有效的。
