Jacobs D G, Wesson D E, Mago-Cao H, Muraji T, Konuma K, Mancer K, Kent G, Heim T
Department of Surgery, Hospital for Sick Children, Toronto, Ontario, Canada.
J Pediatr Gastroenterol Nutr. 1989 Feb;8(2):245-51. doi: 10.1097/00005176-198902000-00020.
Controversy continues regarding the nutritional value to the fetus of swallowed amniotic fluid. To clarify this issue further, esophageal ligations were performed to prevent deglutition in utero in 63 fetal rabbits during the final trimester of pregnancy. Compared with sham-operated littermate controls, the fetuses that were ligated for periods of 4, 5, or 6 days showed significant reductions in weight of 6.1, 18.9, and 9.2%, respectively. These results compare well with the magnitude of weight reduction seen clinically in patients with esophageal atresia. Significant but less consistent reductions were also noted in crown-rump length and biparietal diameter. No significant differences were seen in either body composition or gastrointestinal tract histology. These results indicate that swallowed amniotic fluid does play a role in fetal nutrition and may be particularly important in the later stages of gestation when placental function is limited.
关于胎儿吞咽羊水的营养价值一直存在争议。为了进一步阐明这个问题，在妊娠晚期对63只胎兔进行了食管结扎，以防止其在子宫内吞咽。与假手术的同窝对照相比，结扎4、5或6天的胎儿体重分别显著降低了6.1%、18.9%和9.2%。这些结果与临床上食管闭锁患者体重减轻的程度相当。在顶臀长度和双顶径方面也观察到显著但不太一致的减少。在身体组成或胃肠道组织学方面未发现显著差异。这些结果表明，吞咽羊水在胎儿营养中确实起作用，并且在妊娠后期胎盘功能有限时可能特别重要。
