Moya-Dionisio V, Díaz-Zabala M, Ibáñez-Fernández A, Suárez-Leiva P, Martínez-Suárez V, Ordóñez-Álvarez F A, Santos-Rodríguez F
Vanessa Moya-Dionisio, Área de Gestión Clínica de Pediatría. Hospital Universitario Central de Asturias, Oviedo, Spain.
Rev Esp Quimioter. 2016 Jun;29(3):146-50. Epub 2016 Apr 19.
Knowledge of urophatogens and antibiotic susceptibility should be used to assist with empirical urinary tract infection treatment.
We retrospectively analysed local bacterial pattern and antimicrobial susceptibility in positive urinary isolates from paediatric patients collected in the period 2009-2013. Results were compared with a previous study carried out in the same sanitary area between 1995 and 1999.
We identified 2,762 urinary isolates. Escherichia coli was the most common uropathogen (58.9%), followed by Enterococcus sp. (11.6%) and Proteus mirabilis (10.9%). More than 95% of non extended-spectrum beta-lactamase (ESBL)-producing E. coli were susceptible to nitrofurantoin, fosfomycin, cefotaxime and aminoglycosides. However, 56%, 49%, and 22% of the E. coli isolates were resistant to ampicillin, oral first-generation cephalosporins, and trimethoprim-sulfamethoxazole, respectively. Ampicillin and amoxicillin-clavulanate were the most effective antibiotics to treat Enterococcus sp. and P. mirabilis, respectively. Not significant modifications were found compared to results published at the same area in the 90´s.
E. coli was the mostly isolated uropathogen, with a high percentage of resistance to ampicillin, oral first-generation cephalosporins, and trimethoprim-sulfamethoxazole. These urinary isolates and antimicrobial susceptibility patterns were similar to those reported in other paediatric studies and did not show significant changes compared to local previously published results. Thus, it can be considered that the current recommendations about empiric antibiotic therapy in paediatric urinary tract infections remain applicable nowadays.
了解尿路病原体及抗生素敏感性，以辅助经验性治疗尿路感染。
我们回顾性分析了2009年至2013年期间收集的儿科患者尿培养阳性分离株的当地细菌谱及抗菌药物敏感性。将结果与1995年至1999年在同一卫生区域进行的一项先前研究进行比较。
我们共鉴定出2762株尿培养分离株。大肠埃希菌是最常见的尿路病原体（58.9%），其次是肠球菌属（11.6%）和奇异变形杆菌（10.9%）。超过95%的非产超广谱β-内酰胺酶（ESBL）大肠埃希菌对呋喃妥因、磷霉素、头孢噻肟和氨基糖苷类敏感。然而，分别有56%、49%和22%的大肠埃希菌分离株对氨苄西林、口服第一代头孢菌素和甲氧苄啶-磺胺甲恶唑耐药。氨苄西林和阿莫西林-克拉维酸分别是治疗肠球菌属和奇异变形杆菌最有效的抗生素。与90年代在同一地区发表的结果相比，未发现显著变化。
大肠埃希菌是最常分离出的尿路病原体，对氨苄西林、口服第一代头孢菌素和甲氧苄啶-磺胺甲恶唑耐药率较高。这些尿培养分离株及抗菌药物敏感性模式与其他儿科研究报道的相似，与当地先前发表的结果相比未显示出显著变化。因此，可以认为目前关于儿科尿路感染经验性抗生素治疗的建议如今仍然适用。
