HDAC1通过促进胆囊癌中的上皮-间质转化进程与TCF12结合，从而促进迁移和侵袭。
HDAC1 promoted migration and invasion binding with TCF12 by promoting EMT progress in gallbladder cancer.
作者信息
He Junyi, Shen Sheng, Lu Weiqi, Zhou Yuhong, Hou Yingyong, Zhang Yong, Jiang Ying, Liu Houbao, Shao Yebo
机构信息
Department of General Surgery, Zhongshan Hospital, Fudan University, Shanghai 200032, China.
Department of Clinical Oncology, Zhongshan Hospital, Fudan University, Shanghai 200032, China.
出版信息
Oncotarget. 2016 May 31;7(22):32754-64. doi: 10.18632/oncotarget.8740.
The identification of prognostic markers for gallbladder cancer is needed for clinical practice. Histone deacetylases (HDACs) play an important role in tumor development and progression by modifying histone and non-histone proteins. However, the expression of HDAC1 in patients with gallbladder cancer is still unknown. Here, we reported that HDAC1 expression was elevated in cancerous tissue and correlated with lymph node metastasis and poorer overall survival in patients with GBC. Knockdown of HDAC1 using lentivirus delivery of HDAC1-specific shRNA abrogated the migration and invasion of GBC cells in vitro. TCF-12, as the HDAC1 binding protein, has also correlates with poor prognosis in GBC patients. And there is a positive correlation between HDAC1 and TCF-12 which leading the high invasion and migration ability of GBC cells. Taken together, our data suggested that HDAC1 and TCF-12 are a potential prognostic maker and may be a molecular target for inhibiting invasion and metastasis in GBC.
临床实践需要鉴定胆囊癌的预后标志物。组蛋白去乙酰化酶（HDACs）通过修饰组蛋白和非组蛋白在肿瘤发生和发展中发挥重要作用。然而，HDAC1在胆囊癌患者中的表达情况仍不清楚。在此，我们报道HDAC1在癌组织中表达升高，且与胆囊癌患者的淋巴结转移及较差的总生存期相关。利用慢病毒递送HDAC1特异性shRNA敲低HDAC1可在体外消除胆囊癌细胞的迁移和侵袭。TCF-12作为HDAC1结合蛋白，也与胆囊癌患者的不良预后相关。并且HDAC1与TCF-12之间存在正相关，这导致胆囊癌细胞具有高侵袭和迁移能力。综上所述，我们的数据表明HDAC1和TCF-12是潜在的预后标志物，可能是抑制胆囊癌侵袭和转移的分子靶点。
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