丙酮酸脱氢酶激酶1（PDK1）诱导人胆囊癌中的JunB、上皮-间质转化、细胞迁移和侵袭。
PDK1 induces JunB, EMT, cell migration and invasion in human gallbladder cancer.
作者信息
Lian Shixian, Shao Yebo, Liu Houbao, He Junyi, Lu Weiqi, Zhang Yong, Jiang Ying, Zhu Jun
机构信息
Department of General Surgery, Zhongshan Hospital, Fudan University, Shanghai 200032, China.
出版信息
Oncotarget. 2015 Oct 6;6(30):29076-86. doi: 10.18632/oncotarget.4931.
The protein 3-phosphoinositide-dependent protein kinase 1 (PDK1) is upregulated in cancer. Here we showed that PDK1 stimulated cell proliferation, invasion and metastasis in gallbladder cancer (GBC), by inducing JunB and epithelial-mesenchymal transition. JunB levels were increased in GBC samples and positively correlated with PDK1 levels in tumors. High levels of JunB predicted poor overall survival in GBC patients. Thus, PDK1 functions as a tumor promoter in human GBC by upregulating JunB.
蛋白3-磷酸肌醇依赖性蛋白激酶1（PDK1）在癌症中上调。在此我们表明，PDK1通过诱导JunB和上皮-间质转化，刺激胆囊癌（GBC）细胞的增殖、侵袭和转移。GBC样本中JunB水平升高，且与肿瘤中PDK1水平呈正相关。高水平的JunB预示着GBC患者的总生存期较差。因此，PDK1通过上调JunB在人类GBC中发挥肿瘤促进作用。
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