Gallucci M, Mariotti E, Saraggi D, Stecca T, Oddo M G, Bergamelli C, Boldrini P, Mazzuco S, Ongaro F, Mecocci P, Di Paola F, Bendini M, Forloni G L, Albani D, Antuono P, Caberlotto L, Zanardo A, Siculi M, Gajo G B, Durante E, Buscato G
Maurizio Gallucci, MD. Cognitive Impairment Center, General Hospital of Treviso, Piazza Ospedale, 1, I-31100 Treviso, Italy. Phone: +39 (0422) 322-024 e-mail:
J Frailty Aging. 2012;1(1):24-31. doi: 10.14283/jfa.2012.5.
The incidence of dementia increases exponentially with age but knowledge of real disease-modifying interventions is still limited.
To describe the study design and methods of a large prospective cohort study aimed at exploring the complex underlying relationships existing among cognition, frailty, and health-related events in older persons with cognitive impairment.
Prospective cohort study of a representative population of outpatients attending the Treviso Cognitive Impairment Center between 2000 and 2010.
The TREVISO DEMENTIA (TREDEM) Study conducted in Treviso, Italy.
490 men and 874 women, mean age 79.1 ± 7.8 years (range 40.2-100 years).
Physiological data, biochemical parameters, clinical conditions, neuroradiological parameters (e.g., brain atrophy and cerebral vascular lesions identified by computerized tomography scans), neuropsychological assessment, and physical function markers were measured at baseline. Patients were followed-up to 10 years.
The final sample included in the study was predominantly composed of women and characterized by an initial physical function impairment and increased vascular risk profile. Cognitive function of the sample population showed moderate cognitive impairment (Mini Mental State Examination 20.2 ± 6.3; Clinical Dementia Rating 1.2 ± 0.7), and a prevalence of vascular dementia of 26.9%. Cortical, subcortical and hippocampus atrophy were all significantly correlated with age and cognitive function.
Results obtained from the preliminary analyses conducted in the TREDEM study suggest that the database will support the accomplishment of important goals in understanding the nature of cognitive frailty and neurodegenerative diseases.
痴呆症的发病率随年龄呈指数增长，但关于真正能改变疾病进程的干预措施的知识仍然有限。
描述一项大型前瞻性队列研究的研究设计和方法，该研究旨在探索认知功能受损的老年人中认知、衰弱和健康相关事件之间存在的复杂潜在关系。
对2000年至2010年间在特雷维索认知障碍中心就诊的具有代表性的门诊患者人群进行前瞻性队列研究。
在意大利特雷维索进行的特雷维索痴呆症（TREDEM）研究。
490名男性和874名女性，平均年龄79.1±7.8岁（范围40.2 - 100岁）。
在基线时测量生理数据、生化参数、临床状况、神经放射学参数（如通过计算机断层扫描识别的脑萎缩和脑血管病变）、神经心理学评估和身体功能指标。对患者进行了长达10年的随访。
纳入研究的最终样本主要由女性组成，其特征为初始身体功能受损和血管风险状况增加。样本人群的认知功能显示为中度认知障碍（简易精神状态检查表评分为20.2±6.3；临床痴呆评定量表评分为1.2±0.7），血管性痴呆患病率为26.9%。皮质、皮质下和海马萎缩均与年龄和认知功能显著相关。
TREDEM研究的初步分析结果表明，该数据库将有助于实现理解认知衰弱和神经退行性疾病本质的重要目标。
