Department of Chemistry, Graduate School of Natural Science and Technology, Okayama University , 3-1-1 Tsushimanaka, Kita-ku, Okayama 700-8530, Japan.
Himeji EcoTech Co., Ltd., 841-49 Koh, Shirahama-cho, Himeji 672-8023, Japan.
Org Lett. 2016 May 6;18(9):2110-3. doi: 10.1021/acs.orglett.6b00737. Epub 2016 Apr 19.
The first total syntheses of sarcophytonolide H and the originally proposed and correct structures of isosarcophytonolide D have been achieved via transannular ring-closing metathesis (RCM). These total syntheses culminated in the stereostructural confirmation of sarcophytonolide H and the reassignment of isosarcophytonolide D, respectively. The antifouling activity of the synthetic sarcophytonolide H and its analogues was also evaluated.
首次通过[环]迁移关环复分解反应（RCM）实现了软珊瑚内酯 H 和最初提出的正确结构的异软珊瑚内酯 D 的全合成。这些全合成分别以软珊瑚内酯 H 的立体结构确证和异软珊瑚内酯 D 的重新分配而达到高潮。还评估了合成软珊瑚内酯 H 及其类似物的抗污活性。
