Merdad Mazin, Richmon Jeremy D, Quon Harry
Adv Otorhinolaryngol. 2016;78:168-74. doi: 10.1159/000442137. Epub 2016 Apr 12.
The management of malignant salivary gland neoplasms is based on a surgical paradigm, with intraoperative findings and pathology guiding the role of local-regional adjuvant therapy. Despite high rates of local control, local relapse can be a dominant pattern of recurrence, presenting therapeutic challenges. Although an optimal management approach has not been established, aggressive salvage surgery is favored given the morbidity associated with tumor progression at the skull base and the lack of significant response associated with other available treatment modalities. Postoperative radiotherapy has been demonstrated to be effective in the initial management of malignant salivary gland neoplasms and is generally favored for recurrent, surgically resectable tumors for the appropriate patient.
恶性涎腺肿瘤的治疗基于手术模式，术中发现和病理结果指导局部区域辅助治疗的作用。尽管局部控制率较高，但局部复发可能是主要的复发模式，带来治疗挑战。虽然尚未确立最佳的治疗方法，但鉴于颅底肿瘤进展相关的发病率以及其他现有治疗方式缺乏显著反应，积极的挽救性手术更受青睐。术后放疗已被证明在恶性涎腺肿瘤的初始治疗中有效，对于合适的患者，对于复发且可手术切除的肿瘤通常更受青睐。
