METHODS AND CONSIDERATIONS FOR EXPERIMENTAL EVALUATION OF ANTIEPILEPTIC DRUGS.

Research into epilepsy and development of antiepileptic drugs relies heavily on studies in experimental animals. Though the conventional pentylenetetrazole-induced seizures and electroshock-induced seizures remain the mainstay of any antiepileptic drug screening protocol, considering the diversity of seizure types and underlying pathologies encountered in epilectics, numerous other seizure models have been developed. Some of these experimental models of seizures and considerations governing their selection are reviewed.