Wang Xu-Li, Xu Kang-Ping, Long Hong-Ping, Zou Hui, Cao Xiao-Zheng, Zhang Kai, Hu Jian-Zhong, He Shu-Jin, Zhu Gang-Zhi, He Xiao-Ai, Xu Ping-Sheng, Tan Gui-Shan
Xiangya Hospital, Central South University, Changsha 410008, China; School of Pharmaceutical Sciences, Central South University, Changsha 410013, China.
School of Pharmaceutical Sciences, Central South University, Changsha 410013, China.
Fitoterapia. 2016 Jun;111:58-65. doi: 10.1016/j.fitote.2016.04.010. Epub 2016 Apr 16.
Hericium erinaceus is a well-known medicinal and edible mushroom, which is considered as a potential source to obtain antitumor candidates. In this work, five new isoindolinones, named erinaceolactams A-E (1-5), along with five known compounds (6-10), were isolated from 70% ethanol extract of the fruiting bodies of H. erinaceus. The structures of new compounds were validated by HRESIMS and 1D, 2D NMR. It's worth mentioning that there are two pairs of isomers included in the new compounds. Moreover, their cytotoxicity against metastatic human hepatocellular carcinoma cell lines SMMC-7221 and MHCC-97H were evaluated. The results showed that compounds 6 and 7 exhibited promising inhibitory potency against the growth of two cell lines.
猴头菌是一种著名的药食两用真菌，被认为是获取抗肿瘤候选物的潜在来源。在本研究中，从猴头子实体的70%乙醇提取物中分离出了5个新的异吲哚啉酮类化合物，命名为猴头菌素A-E（1-5），以及5个已知化合物（6-10）。新化合物的结构通过高分辨电喷雾电离质谱（HRESIMS）和一维、二维核磁共振（1D、2D NMR）进行了确证。值得一提的是，新化合物中包含两对异构体。此外，还评估了它们对转移性人肝癌细胞系SMMC-7221和MHCC-97H的细胞毒性。结果表明，化合物6和7对两种细胞系的生长表现出有前景的抑制活性。
