一种来自猴头菇子实体的新型脑苷脂及其在癌症治疗中的适用性。
A new cerebroside from the fruiting bodies of Hericium erinaceus and its applicability to cancer treatment.
作者信息
Lee Seoung Rak, Jung Kiwon, Noh Hyung Jun, Park Yong Joo, Lee Hye Lim, Lee Kang Ro, Kang Ki Sung, Kim Ki Hyun
机构信息
School of Pharmacy, Sungkyunkwan University, Suwon 440-746, Republic of Korea.
College of Pharmacy, CHA University, Pocheon 487-010, Republic of Korea.
出版信息
Bioorg Med Chem Lett. 2015 Dec 15;25(24):5712-5. doi: 10.1016/j.bmcl.2015.10.092. Epub 2015 Nov 2.
A new cerebroside, cerebroside E (1) was isolated from the fruiting bodies of Hericium erinaceus (Hericiaceae). The structure of 1 was elucidated by a combination of extensive spectroscopic analyses, including extensive 2D NMR, HR-MS, and chemical reactions. Compound 1 was evaluated for its applicability to medicinal use in several human diseases using cell-based assays. As a result, compound 1 attenuated cisplatin-induced nephrotoxicity in LLC-PK1 cells and exhibited a significant inhibitory effect on angiogenesis in HUVECs. These results collectively reflect the beneficial effects of compound 1 in cancer treatment.
从猴头菌（猴头菌科）的子实体中分离出一种新的脑苷脂，即脑苷脂E（1）。通过广泛的光谱分析，包括广泛的二维核磁共振、高分辨质谱和化学反应相结合的方法阐明了1的结构。使用基于细胞的试验评估了化合物1在几种人类疾病中的药用适用性。结果，化合物1减轻了顺铂诱导的LLC-PK1细胞肾毒性，并对人脐静脉内皮细胞（HUVECs）的血管生成表现出显著的抑制作用。这些结果共同反映了化合物1在癌症治疗中的有益作用。
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