Lee Seoung Rak, Jung Kiwon, Noh Hyung Jun, Park Yong Joo, Lee Hye Lim, Lee Kang Ro, Kang Ki Sung, Kim Ki Hyun
School of Pharmacy, Sungkyunkwan University, Suwon 440-746, Republic of Korea.
College of Pharmacy, CHA University, Pocheon 487-010, Republic of Korea.
Bioorg Med Chem Lett. 2015 Dec 15;25(24):5712-5. doi: 10.1016/j.bmcl.2015.10.092. Epub 2015 Nov 2.
A new cerebroside, cerebroside E (1) was isolated from the fruiting bodies of Hericium erinaceus (Hericiaceae). The structure of 1 was elucidated by a combination of extensive spectroscopic analyses, including extensive 2D NMR, HR-MS, and chemical reactions. Compound 1 was evaluated for its applicability to medicinal use in several human diseases using cell-based assays. As a result, compound 1 attenuated cisplatin-induced nephrotoxicity in LLC-PK1 cells and exhibited a significant inhibitory effect on angiogenesis in HUVECs. These results collectively reflect the beneficial effects of compound 1 in cancer treatment.
从猴头菌（猴头菌科）的子实体中分离出一种新的脑苷脂，即脑苷脂E（1）。通过广泛的光谱分析，包括广泛的二维核磁共振、高分辨质谱和化学反应相结合的方法阐明了1的结构。使用基于细胞的试验评估了化合物1在几种人类疾病中的药用适用性。结果，化合物1减轻了顺铂诱导的LLC-PK1细胞肾毒性，并对人脐静脉内皮细胞（HUVECs）的血管生成表现出显著的抑制作用。这些结果共同反映了化合物1在癌症治疗中的有益作用。
