Institute of Photonics, University of Eastern Finland, P.O. Box 111, FI-80101 Joensuu, Finland.
Institute of Photonics, University of Eastern Finland, P.O. Box 111, FI-80101 Joensuu, Finland.
Int J Pharm. 2016 Jun 15;506(1-2):87-92. doi: 10.1016/j.ijpharm.2016.04.026. Epub 2016 Apr 16.
A structure parameter that can be used to predict the pattern of arrangement of porous inclusions in pharmaceutical tablets is introduced. By utilizing the effective refractive index of a pharmaceutical tablet obtained from terahertz time-domain measurements, we have shown that there exists a promising correlation between the calculated structural parameter and the porosity of training sets of pharmaceutical tablets, having well-defined characterization. Knowing of the structural arrangement, i.e. combined constituent skeletal-pore elements in series, parallel or mixed within porous media, could serve as a basis for understanding the ingress and permeation of liquids in such media. In the realm of pharmaceutical applications, such knowledge of the structural arrangement of air voids within a medicinal tablet could enable correlation with mechanical strength and dissolution behaviour in aqueous systems.
引入了一个可用于预测药物片剂中多孔包裹体排列模式的结构参数。通过利用太赫兹时域测量得到的药物片剂的有效折射率，我们表明，在具有明确定量特征的药物片剂训练集中，计算得到的结构参数与孔隙率之间存在着有希望的相关性。了解结构排列，即多孔介质中串联、并联或混合的组合组成骨架-孔隙元素，可以为理解液体在这种介质中的进入和渗透提供基础。在药物应用领域，了解药物片剂中空气空隙的结构排列可以与机械强度和在水系统中的溶解行为相关联。
