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使用太赫兹脉冲对双凸片进行无创孔隙率测量。

Noninvasive porosity measurement of biconvex tablets using terahertz pulses.

作者信息

Bawuah Prince, Ervasti Tuomas, Tan Nicholas, Zeitler J Axel, Ketolainen Jarkko, Peiponen Kai-Erik

机构信息

Institute of Photonics, University of Eastern Finland, P.O. Box 111, FI-80101 Joensuu, Finland.

School of Pharmacy, Promis Centre, University of Eastern Finland, P.O. Box 1617, FI-70211, Kuopio, Finland.

出版信息

Int J Pharm. 2016 Jul 25;509(1-2):439-443. doi: 10.1016/j.ijpharm.2016.06.023. Epub 2016 Jun 8.

Abstract

Biconvex pharmaceutical microcrystalline cellulose (MCC) compacts were investigated by the detection of terahertz (THz) pulse delay in the transmission measurement mode. The dimensions of the tablets were kept as constants but the porosity was a priori known variable. It is shown that the porosity of the biconvex compact has a linear correlation with the THz pulse delay. By constructing a calibration line between these two parameters (i.e. porosity and THz pulse delay), it is possible to non-invasively detect porosity of biconvex tablets. We suggest that this preliminary study could be the starting point of in-depth future studies on the screening of porosity and related properties of real biconvex pharmaceutical tablets using terahertz sensing techniques.

摘要

通过在透射测量模式下检测太赫兹(THz)脉冲延迟,对双凸形药用微晶纤维素(MCC)压片进行了研究。片剂的尺寸保持不变,但孔隙率是一个预先已知的变量。结果表明,双凸形压片的孔隙率与太赫兹脉冲延迟呈线性相关。通过构建这两个参数(即孔隙率和太赫兹脉冲延迟)之间的校准线,可以无创地检测双凸形片剂的孔隙率。我们认为,这项初步研究可能是未来使用太赫兹传感技术深入研究实际双凸形药用片剂孔隙率及相关性质筛选的起点。

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