Dos Santos Alice Hartmann, Vieira Milene Leivas, de Azevedo Camin Nathália, Anselmo-Franci Janete Aparecida, Ceravolo Graziela Scalianti, Pelosi Gislaine Garcia, Moreira Estefânia Gastaldello, Kiss Ana Carolina Inhasz, Mesquita Suzana de Fátima Paccola, Gerardin Daniela Cristina Ceccatto
Department of Physiological Sciences, State University of Londrina, 86051-980 Londrina, Paraná, Brazil.
Department of Morphology, Estomatology and Physiology, University of São Paulo, Ribeirão Preto, São Paulo, Brazil.
Reprod Toxicol. 2016 Jul;62:1-8. doi: 10.1016/j.reprotox.2016.04.006. Epub 2016 Apr 14.
Depression is one of the most prevalent disorders in the world and may occur during pregnancy and postpartum periods. Fluoxetine (FLX) has been widely prescribed for use during depression in pregnancy and lactation. This study aimed to investigate if in utero and lactational exposure to FLX could compromise reproductive parameters in female offspring. Wistar rats received, by daily gavage, FLX 5mg/kg or 0.3ml of water (control group) from the first gestational day until weaning (21 days). Assessments in the female offspring included: body weight, anogenital distance, vaginal opening, first estrus, estrous cycle, reproductive organs weight, uterine morphometric analyses, ovarian follicle and corpora lutea counting, estradiol plasmatic concentration, sexual behavior, maternal behavior and fertility test. Exposure to FLX delayed the puberty onset in female pups. The present study demonstrated that developmental exposure to FLX can deregulate the neuroendocrine hormonal control of female offspring during prepubertal and pubertal periods.
抑郁症是世界上最常见的疾病之一，可能发生在孕期和产后。氟西汀（FLX）已被广泛用于孕期和哺乳期抑郁症的治疗。本研究旨在调查子宫内和哺乳期接触氟西汀是否会损害雌性后代的生殖参数。从妊娠第一天到断奶（21天），Wistar大鼠每天通过灌胃给予5mg/kg氟西汀或0.3ml水（对照组）。对雌性后代的评估包括：体重、肛门生殖器距离、阴道开口、首次发情、发情周期、生殖器官重量、子宫形态分析、卵巢卵泡和黄体计数、血浆雌二醇浓度、性行为、母性行为和生育力测试。接触氟西汀会延迟雌性幼崽的青春期开始。本研究表明，发育过程中接触氟西汀会在青春期前和青春期期间破坏雌性后代的神经内分泌激素控制。
