Animal and Dairy Sciences Department, University of Wisconsin-Madison, Madison, WI, USA.
J Mammary Gland Biol Neoplasia. 2023 Apr 22;28(1):7. doi: 10.1007/s10911-023-09535-z.
Lactation is a physiological adaptation of the class Mammalia and is a product of over 200 million years of evolution. During lactation, the mammary gland orchestrates bone metabolism via serotonin signaling in order to provide sufficient calcium for the offspring in milk. The role of serotonin in bone remodeling was first discovered over two decades ago, and the interplay between serotonin, lactation, and bone metabolism has been explored in the years following. It is estimated that postpartum depression affects 10-15% of the population, and selective serotonin reuptake inhibitors (SSRI) are often used as the first-line treatment. Studies conducted in humans, nonhuman primates, sheep, and rodents have provided evidence that there are consequences on both parent and offspring when serotonin signaling is disrupted during the peripartal period; however, the long-term consequences of disruption of serotonin signaling via SSRIs during the peripartal period on the maternal and offspring skeleton are not fully known. This review will focus on the relationship between the mammary gland, serotonin, and bone remodeling during the peripartal period and the skeletal consequences of the dysregulation of the serotonergic system in both human and animal studies.
哺乳是哺乳类动物的一种生理适应，是 2 亿多年进化的产物。在哺乳期间，乳腺通过血清素信号来协调骨骼代谢，以便在乳汁中为后代提供足够的钙。二十多年前，人们首次发现血清素在骨重塑中的作用，此后，人们一直在探索血清素、哺乳和骨代谢之间的相互作用。据估计，产后抑郁症影响了 10-15%的人群，选择性 5-羟色胺再摄取抑制剂（SSRIs）通常被用作一线治疗药物。在人类、非人类灵长类动物、绵羊和啮齿动物中进行的研究提供了证据，表明在围产期期间血清素信号受到干扰时，对母体和后代都有影响；然而，围产期期间通过 SSRIs 干扰血清素信号对母体和后代骨骼的长期影响尚不完全清楚。这篇综述将重点关注围产期期间乳腺、血清素和骨重塑之间的关系，以及在人类和动物研究中，血清素能系统失调对骨骼的影响。
