肋间神经脉冲射频联合普瑞巴林治疗后带状疱疹神经痛时血清脑源性神经营养因子水平的调节
Modulation of serum BDNF levels in postherpetic neuralgia following pulsed radiofrequency of intercostal nerve and pregabalin.
作者信息
Saxena Ashok Kumar, Lakshman Kavitha, Sharma Tusha, Gupta Neha, Banerjee Basu Dev, Singal Archana
机构信息
Pain Clinic, Division under Department of Anaesthesiology, University College of Medical Sciences & Guru Teg Bahadur Hospital, Delhi, India.
Department of Anaesthesiology & Pain Relief, Kidwai Memorial Institute of Oncology, Bangalore, India.
出版信息
Pain Manag. 2016;6(3):217-27. doi: 10.2217/pmt.16.3. Epub 2016 Mar 30.
AIM
To study the modulation of serum BDNF levels following integrated multimodal intervention in postherpetic neuralgia (PHN).
MATERIALS & METHODS: A randomized, double-blind controlled study was undertaken among patients of thoracic PHN where 30 patients received pregabalin with pulsed radiofrequency and 30 controls received pregabalin with sham treatment.
RESULTS
Pain intensity (visual analog scale) was reduced earlier in intervention group (15.3 ± 5.7 at the fourth week) compared with control group (16.3 ± 6.6 at the eighth week). Serum BDNF level increased with time in both the groups with overall increase more pronounced in intervention group.
CONCLUSION
Integrated multimodal therapy using minimally invasive pulsed radiofrequency and pregabalin in PHN was effective in early pain reduction with elevated serum BDNF levels.
目的
研究带状疱疹后神经痛（PHN）综合多模式干预后血清脑源性神经营养因子（BDNF）水平的调节情况。
材料与方法
对胸段PHN患者进行了一项随机、双盲对照研究，其中30例患者接受普瑞巴林联合脉冲射频治疗，30例对照组患者接受普瑞巴林联合假治疗。
结果
与对照组（第8周时为16.3±6.6）相比，干预组（第4周时为15.3±5.7）疼痛强度（视觉模拟量表）下降更早。两组血清BDNF水平均随时间升高，且干预组总体升高更为明显。
结论
在PHN中使用微创脉冲射频和普瑞巴林的综合多模式疗法在早期减轻疼痛及提高血清BDNF水平方面有效。
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