Okada Shigeru
Department of Medical Research, Ministry of Health, Yangon, Myanmar.
Acta Med Okayama. 2016;70(2):103-10. doi: 10.18926/AMO/54189.
Molecular and epidemiologic investigations suggest a causal role for human papillomavirus (HPV) in anogenital cancers. This study identified oncogenic HPV genotypes in anogenital cancers among men and women in a 2013 cross-sectional descriptive study in Myanmar. In total, 100 biopsy tissues of histologically confirmed anogenital cancers collected in 2008-2012 were studied, including 30 penile and 9 anal cancers from Yangon General Hospital and 61 vulvar cancers from Central Women's Hospital, Yangon. HPV-DNA testing and genotyping were performed by polymerase chain reaction-restriction fragment length polymorphism. Overall, 34% of anogenital cancers were HPV-positive. HPV was found in 44.4% of anal (4/9), 36.1% of vulvar (22/61), and 26.7% of penile (8/30) cancers. The most frequent genotypes in anal cancers were HPV 16 (75% ) and 18 (25% ). In vulvar cancers, HPV 33 was most common (40.9% ), followed by 16 (31.8% ), 31 (22.7% ), and 18 (4.6% ). In penile cancers, HPV 16 (62.5% ) was most common, followed by 33 (25% ) and 18 (12.5% ). This is the first report of evidencebased oncogenic HPV genotypes in anogenital cancers among men and women in Myanmar. This research provides valuable information for understanding the burden of HPV-associated cancers of the anus, penis, and vulva and considering the effectiveness of prophylactic HPV vaccination.
分子和流行病学调查表明，人乳头瘤病毒（HPV）在肛门生殖器癌中起因果作用。本研究在2013年缅甸的一项横断面描述性研究中，确定了男性和女性肛门生殖器癌中的致癌HPV基因型。总共研究了2008 - 2012年收集的100例经组织学确诊的肛门生殖器癌活检组织，包括仰光总医院的30例阴茎癌和9例肛门癌，以及仰光中央妇女医院的61例外阴癌。通过聚合酶链反应 - 限制性片段长度多态性进行HPV - DNA检测和基因分型。总体而言，34%的肛门生殖器癌HPV呈阳性。在44.4%的肛门癌（4/9）、36.1%的外阴癌（22/61）和26.7%的阴茎癌（8/30）中发现了HPV。肛门癌中最常见的基因型是HPV 16（75%）和18（25%）。在外阴癌中，HPV 33最常见（40.9%），其次是16（31.8%）、31（22.7%）和18（4.6%）。在阴茎癌中，HPV 16（62.5%）最常见，其次是33（25%）和18（12.5%）。这是缅甸男性和女性肛门生殖器癌中基于证据的致癌HPV基因型的首次报告。这项研究为了解肛门、阴茎和外阴HPV相关癌症的负担以及考虑预防性HPV疫苗接种的有效性提供了有价值的信息。
