Melbye M, Frisch M
Department of Epidemiology Research, Danish Epidemiology Science Centre, Statens Serum Institut, Copenhagen, Denmark.
Semin Cancer Biol. 1998 Aug;8(4):307-13. doi: 10.1006/scbi.1998.0081.
There is substantial evidence to suggest that common risk factors exist for cancer of the cervix and other anogenital cancers. Cervical cancer has been etiologically linked with venereal types of human papillomavirus (HPV) and the same types of HPV are being found in other anogenital tissues. The question is to what extent these HPV types may also contribute to carcinogenesis in anogenital cancer other than cervical cancer. In this review some general aspects of the natural history of HPV are presented followed by a description of the incidence and risk factors for anal, vulvar, and penile cancer. Main focus is given to the evidence for an association between these cancers and HPV.
有大量证据表明，子宫颈癌和其他肛门生殖器癌症存在共同的风险因素。子宫颈癌在病因上与性传播类型的人乳头瘤病毒（HPV）有关，并且在其他肛门生殖器组织中也发现了相同类型的HPV。问题是这些HPV类型在多大程度上也可能导致除子宫颈癌之外的其他肛门生殖器癌症的致癌作用。在这篇综述中，首先介绍了HPV自然史的一些一般方面，随后描述了肛门癌、外阴癌和阴茎癌的发病率及风险因素。主要关注这些癌症与HPV之间关联的证据。
