Chen Shunyu, He Zhihang, Xu Guojie, Xiao Xiufeng
a College of Chemistry and Chemical Engineering , Fujian Normal University , Fuzhou , China.
J Biomater Sci Polym Ed. 2016 Jul;27(10):1058-68. doi: 10.1080/09205063.2016.1180830. Epub 2016 May 4.
Modified nanofibrous Poly(L-lactic acid) (PLLA) scaffolds were fabricated by aminolysis combined with thermally induced phase separation technique using PLLA/1,4-dioxane/urea-NaOH-H2O system at -40 °C freeze temperature. Aminolysis led to the modification of scaffold resulting in enhancement in the bioactivity. The surface of the modified nanofibrous scaffold provided a good environment for attachment and proliferation of MC3T3-E1 subclone 14 cells, exhibiting significant potential for bone tissue regeneration and for promoting cytocompatibility.
采用氨解结合热致相分离技术，在-40°C冷冻温度下，使用聚左旋乳酸（PLLA）/1,4-二氧六环/尿素-氢氧化钠-水体系制备了改性纳米纤维聚左旋乳酸（PLLA）支架。氨解导致支架改性，从而提高了生物活性。改性纳米纤维支架的表面为MC3T3-E1亚克隆14细胞的附着和增殖提供了良好的环境，在骨组织再生和促进细胞相容性方面具有显著潜力。
